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MedKoo Cat#: 563801 | Name: DB2313 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets.

Chemical Structure

DB2313 HCl
DB2313 HCl
CAS#2170606-75-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 563801

Name: DB2313 HCl

CAS#: 2170606-75-2 (HCl)

Chemical Formula: C42H45Cl4FN8O2

Exact Mass: 0.0000

Molecular Weight: 854.67

Elemental Analysis: C, 59.02; H, 5.31; Cl, 16.59; F, 2.22; N, 13.11; O, 3.74

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 Ready to ship
10mg USD 250.00 Ready to ship
25mg USD 550.00 Ready to ship
50mg USD 950.00 Ready to ship
100mg USD 1,650.00 Ready to ship
200mg USD 2,650.00 Ready to ship
500mg USD 3,750.00 Ready to ship
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Related CAS #
2170606-75-2 (HCl) 2170606-74-1 (free base)
Synonym
DB2313 HCl; DB 2313 HCl; DB-2313 HCl; DB2313 tetrahydrochloride
IUPAC/Chemical Name
2,2'-((((2-Fluoro-1,3-phenylene)bis(methylene))bis(oxy))bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide) tetrahydrochloride
InChi Key
VTQBTZDMPNTLGK-UHFFFAOYSA-N
InChi Code
InChI=1S/C42H41FN8O2.4ClH/c1-24(2)46-39(44)28-12-18-34-36(20-28)50-41(48-34)26-8-14-32(15-9-26)52-22-30-6-5-7-31(38(30)43)23-53-33-16-10-27(11-17-33)42-49-35-19-13-29(21-37(35)51-42)40(45)47-25(3)4;;;;/h5-21,24-25H,22-23H2,1-4H3,(H2,44,46)(H2,45,47)(H,48,50)(H,49,51);4*1H
SMILES Code
FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>96% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 854.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tu J, Chen W, Fang Y, Han D, Chen Y, Jiang H, Tan X, Xu Z, Wu X, Wang H, Zhu X, Hong W, Li Z, Zhu C, Wang X, Wei W. PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes. Ann Rheum Dis. 2023 Feb;82(2):198-211. doi: 10.1136/ard-2022-222708. Epub 2022 Oct 5. PMID: 36198439; PMCID: PMC9887374. 2: Tu X, Kim RY, Brown AC, de Jong E, Jones-Freeman B, Ali MK, Gomez HM, Budden KF, Starkey MR, Cameron GJM, Loering S, Nguyen DH, Nair PM, Haw TJ, Alemao CA, Faiz A, Tay HL, Wark PAB, Knight DA, Foster PS, Bosco A, Horvat JC, Hansbro PM, Donovan C. Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap. J Allergy Clin Immunol. 2022 Oct;150(4):817-829.e6. doi: 10.1016/j.jaci.2022.04.032. Epub 2022 May 25. PMID: 35643377. 3: Tu X, Gomez HM, Kim RY, Brown AC, de Jong E, Galvao I, Faiz A, Bosco A, Horvat JC, Hansbro P, Donovan C. Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma. Respir Res. 2023 Jan 25;24(1):32. doi: 10.1186/s12931-022-02298-x. PMID: 36698141; PMCID: PMC9878882. 4: Ninomiya I, Koyama A, Otsu Y, Onodera O, Kanazawa M. Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke. Front Cell Neurosci. 2023 Aug 11;17:1225504. doi: 10.3389/fncel.2023.1225504. Erratum in: Front Cell Neurosci. 2024 Feb 05;18:1372045. doi: 10.3389/fncel.2024.1372045. PMID: 37636590; PMCID: PMC10457112. 5: Zhang S, Zhao S, Qi Y, Li B, Wang H, Pan Z, Xue H, Jin C, Qiu W, Chen Z, Guo Q, Fan Y, Xu J, Gao Z, Wang S, Guo X, Deng L, Ni S, Xue F, Wang J, Zhao R, Li G. SPI1-induced downregulation of FTO promotes GBM progression by regulating pri- miR-10a processing in an m6A-dependent manner. Mol Ther Nucleic Acids. 2022 Jan 1;27:699-717. doi: 10.1016/j.omtn.2021.12.035. PMID: 35317283; PMCID: PMC8905236.