Synonym
KW 5805; KW5805; KW-5805
IUPAC/Chemical Name
5-((2-(Diethylamino)ethyl)amino)-5,11-dihydro(1)-benzoxepino(3,4-b)pyridine
InChi Key
BXCYELSSZNDSFJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N3O/c1-3-22(4-2)13-12-21-19-15-9-7-11-20-17(15)14-23-18-10-6-5-8-16(18)19/h5-11,19,21H,3-4,12-14H2,1-2H3
SMILES Code
CCN(CCNC1C2=CC=CC=C2OCC3=NC=CC=C31)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
311.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tanaka H, Kosaka N, Tomaru A, Shuto K, Ogihara T, Sato N. Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Scand J Gastroenterol Suppl. 1989;162:170-3. PubMed PMID: 2595291.
2: Yano S, Kimura Y, Horie S, Ito K, Yamada N, Mizuno M, Watanabe K. Centrally mediated inhibitory effect of 5-[2-(diethylamino)ethyl]amino-5,11-dihydro[1]benzoxepino[3,4- b]pyridine trihydrochloride (KW-5805) on gastric acid secretion in rats. Jpn J Pharmacol. 1990 Feb;52(2):287-93. PubMed PMID: 2313937.
3: Kosaka N, Tanaka H, Ishii A, Shuto K. [Effect of 5-[2-(diethylamino)ethyl]amino-5,11- dihydro[1]benzoxepino[3,4-b]pyridine trihydrochloride (KW-5805) on the biosynthesis of rat gastric mucus]. Nihon Yakurigaku Zasshi. 1994 Dec;104(6):459-68. Japanese. PubMed PMID: 7851819.
4: Kumazawa T, Harakawa H, Obase H, Oiji Y, Tanaka H, Shuto K, Ishii A, Oka T, Nakamizo N. Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines. J Med Chem. 1988 Apr;31(4):779-85. PubMed PMID: 3351856.
5: Kosaka N, Tanaka H, Ishii A, Shuto K. [Effect of KW-5805 on gastric mucus changes induced by water immersion-restraint stress and aspirin in rats]. Nihon Yakurigaku Zasshi. 1994 Oct;104(4):293-302. Japanese. PubMed PMID: 7959420.
6: Kosaka N, Tanaka H, Tomaru A, Ishii A, Shuto K. Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion. Jpn J Pharmacol. 1994 Aug;65(4):305-12. PubMed PMID: 7990267.
7: Uckert B, Kobayashi S, Maier-Lenz H. Tolerance and pharmacokinetics of a new antiulcer compound in man after single oral doses. Arzneimittelforschung. 1989 Jul;39(7):805-8. PubMed PMID: 2783183.
