2C07 | CAS#2230185-95-0 | switch-II binder

MedKoo Cat#: 563758 | Name: 2C07

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2C07 is a Novel switch-II binder. 2C07 alters nucleotide preference and inhibits SOS binding and catalyzed nucleotide exchange.

Chemical Structure

2C07

CAS#2230185-95-0 (free base)

Theoretical Analysis

MedKoo Cat#: 563758

Name: 2C07

CAS#: 2230185-95-0 (free base)

Chemical Formula: C19H25F3N4O2S2

Exact Mass: 462.1400

Molecular Weight: 462.55

Elemental Analysis: C, 49.34; H, 5.45; F, 12.32; N, 12.11; O, 6.92; S, 13.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

2230185-95-0 (free base) 2230185-96-1 (formic acid)

Synonym

2C07; 2C-07; 2C 07;

IUPAC/Chemical Name

N-(3-((2-(Dimethylamino)ethyl)disulfaneyl)propyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

InChi Key

RWHKAUSDYJQSDY-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H25F3N4O2S2/c1-25(2)10-12-30-29-11-4-9-23-18(27)16-13-24-26(17(16)19(20,21)22)14-5-7-15(28-3)8-6-14/h5-8,13H,4,9-12H2,1-3H3,(H,23,27)

SMILES Code

O=C(C1=C(C(F)(F)F)N(C2=CC=C(OC)C=C2)N=C1)NCCCSSCCN(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in customs.

Storage Condition

Dry, dark, and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol. 2017 Dec 21;24(12):1455-1466.e14. doi: 10.1016/j.chembiol.2017.08.025. Epub 2017 Oct 12. PubMed PMID: 29033317; PubMed Central PMCID: PMC5915340. 2: Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W. Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae. J Bacteriol. 2015 Nov 9;198(3):463-76. doi: 10.1128/JB.00360-15. Print 2016 Feb 1. PubMed PMID: 26553852; PubMed Central PMCID: PMC4719456. 3: Mao Q, Duax WL, Umland TC. Crystallization and X-ray diffraction analysis of the beta-ketoacyl-acyl carrier protein reductase FabG from Aquifex aeolicus VF5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt 2):106-9. Epub 2007 Jan 17. PubMed PMID: 17277451; PubMed Central PMCID: PMC2330128. 4: Wickramasinghe SR, Inglis KA, Urch JE, Müller S, van Aalten DM, Fairlamb AH. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Biochem J. 2006 Jan 15;393(Pt 2):447-57. PubMed PMID: 16225460; PubMed Central PMCID: PMC1360695.