MedKoo Cat#: 563717 | Name: BAPTA free acid
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.

Chemical Structure

BAPTA free acid
BAPTA free acid
CAS#85233-19-8 (free acid)

Theoretical Analysis

MedKoo Cat#: 563717

Name: BAPTA free acid

CAS#: 85233-19-8 (free acid)

Chemical Formula: C22H24N2O10

Exact Mass: 476.1431

Molecular Weight: 476.43

Elemental Analysis: C, 55.46; H, 5.08; N, 5.88; O, 33.58

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 450.00 2 Weeks
1g USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
BAPTA; BAPTA free acid;
IUPAC/Chemical Name
1,2-Bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
InChi Key
FTEDXVNDVHYDQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)
SMILES Code
O=C(O)CN(CC(O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O)=O)CC(O)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 476.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bootman MD, Allman S, Rietdorf K, Bultynck G. Deleterious effects of calcium indicators within cells; an inconvenient truth. Cell Calcium. 2018 Jul;73:82-87. doi: 10.1016/j.ceca.2018.04.005. Epub 2018 Apr 15. Review. PubMed PMID: 29689523. 2: Grover AK. Sodium-Calcium Exchanger in Pig Coronary Artery. Adv Pharmacol. 2017;78:145-170. doi: 10.1016/bs.apha.2016.06.001. Epub 2016 Jul 15. Review. PubMed PMID: 28212796. 3: Wang LY, Augustine GJ. Presynaptic nanodomains: a tale of two synapses. Front Cell Neurosci. 2015 Jan 26;8:455. doi: 10.3389/fncel.2014.00455. eCollection 2014. Review. PubMed PMID: 25674049; PubMed Central PMCID: PMC4306312. 4: Rcom-H'cheo-Gauthier A, Goodwin J, Pountney DL. Interactions between calcium and alpha-synuclein in neurodegeneration. Biomolecules. 2014 Aug 14;4(3):795-811. doi: 10.3390/biom4030795. Review. PubMed PMID: 25256602; PubMed Central PMCID: PMC4192672. 5: Shirakawa H. [Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation]. Yakugaku Zasshi. 2012;132(5):587-93. Review. Japanese. PubMed PMID: 22687694. 6: Brodsky VY, Zvezdina ND. Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo. Cell Biol Int. 2010 Dec;34(12):1199-204. doi: 10.1042/CBI20100036. Review. PubMed PMID: 21067519. 7: Kim N, Cannell MB, Hunter PJ. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Prog Biophys Mol Biol. 2010 Sep;103(1):28-34. doi: 10.1016/j.pbiomolbio.2010.05.004. Epub 2010 May 27. Review. PubMed PMID: 20553743. 8: Muller KJ, Tsechpenakis G, Homma R, Nicholls JG, Cohen LB, Eugenin J. Optical analysis of circuitry for respiratory rhythm in isolated brainstem of foetal mice. Philos Trans R Soc Lond B Biol Sci. 2009 Sep 12;364(1529):2485-91. doi: 10.1098/rstb.2009.0070. Review. PubMed PMID: 19651650; PubMed Central PMCID: PMC2865113. 9: Paredes RM, Etzler JC, Watts LT, Zheng W, Lechleiter JD. Chemical calcium indicators. Methods. 2008 Nov;46(3):143-51. doi: 10.1016/j.ymeth.2008.09.025. Epub 2008 Oct 16. Review. PubMed PMID: 18929663; PubMed Central PMCID: PMC2666335. 10: Arai AC. The role of kisspeptin and GPR54 in the hippocampus. Peptides. 2009 Jan;30(1):16-25. doi: 10.1016/j.peptides.2008.07.023. Epub 2008 Aug 13. Review. PubMed PMID: 18765263. 11: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866. 12: Sergeev IN. Calcium signaling in cancer and vitamin D. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):145-51. Epub 2005 Aug 2. Review. PubMed PMID: 16081284. 13: Hübener M, Bonhoeffer T. Visual cortex: two-photon excitement. Curr Biol. 2005 Mar 29;15(6):R205-8. Review. PubMed PMID: 15797013. 14: Gall D, Roussel C, Nieus T, Cheron G, Servais L, D'Angelo E, Schiffmann SN. Role of calcium binding proteins in the control of cerebellar granule cell neuronal excitability: experimental and modeling studies. Prog Brain Res. 2005;148:321-8. Review. PubMed PMID: 15661200. 15: D'Angelo E, Rossi P, Gall D, Prestori F, Nieus T, Maffei A, Sola E. Long-term potentiation of synaptic transmission at the mossy fiber-granule cell relay of cerebellum. Prog Brain Res. 2005;148:69-80. Review. PubMed PMID: 15661182. 16: Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review. PubMed PMID: 15561916. 17: Yeung PK. DP-b99 (D-Pharm). Curr Opin Investig Drugs. 2004 Jan;5(1):90-4. Review. PubMed PMID: 14983980. 18: Balaban PM, Korshunova TA, Bravarenko NI. Postsynaptic calcium contributes to reinforcement in a three-neuron network exhibiting associative plasticity. Eur J Neurosci. 2004 Jan;19(2):227-33. Review. PubMed PMID: 14725616. 19: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027. 20: Kuwabara M, Takahashi K, Inanami O. Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res. 2003 Sep;44(3):203-9. Review. PubMed PMID: 14646222.