MedKoo Cat#: 471125 | Name: Guadecitabine sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Guadecitabine sodium is a second-generation DNA methyltransferases (DNMT) inhibitor for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).

Chemical Structure

Guadecitabine sodium
Guadecitabine sodium
CAS#929904-85-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 471125

Name: Guadecitabine sodium

CAS#: 929904-85-8 (sodium)

Chemical Formula: C18H23N9NaO10P

Exact Mass: 0.0000

Molecular Weight: 579.40

Elemental Analysis: C, 37.31; H, 4.00; N, 21.76; Na, 3.97; O, 27.61; P, 5.35

Price and Availability

Size Price Availability Quantity
1mg USD 650.00 2 Weeks
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Synonym
SGI110 sodium; SGI-110 sodium; SGI 110 sodium; S110; Guadecitabine sodium
IUPAC/Chemical Name
sodium (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) phosphate
InChi Key
XLHBNJPXFOZFNJ-BYKQGDNKSA-M
InChi Code
InChI=1S/C18H24N9O10P.Na/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30;/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30);/q;+1/p-1/t7-,8-,9+,10+,11+,12+;/m0./s1
SMILES Code
O=C1C2=C(NC(N)=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COP(O[C@@H]4[C@H](O[C@H](C4)N5C=NC(N)=NC5=O)CO)([O-])=O)O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 579.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL