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MedKoo Cat#: 461908 | Name: Flunixin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs.

Chemical Structure

Flunixin
Flunixin
CAS#38677-85-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 461908

Name: Flunixin

CAS#: 38677-85-9 (free acid)

Chemical Formula: C14H11F3N2O2

Exact Mass: 296.0773

Molecular Weight: 296.24

Elemental Analysis: C, 56.76; H, 3.74; F, 19.24; N, 9.46; O, 10.80

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
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Related CAS #
38677-85-9 (free acid) 42461-84-7 (meglumine)
Synonym
Flunixin; Flunixine; Flunixino; Flunixinum; SCH 14714; SCH-14714; SCH14714
IUPAC/Chemical Name
2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinic acid
InChi Key
NOOCSNJCXJYGPE-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)
SMILES Code
O=C(O)C1=C(NC2=CC=CC(C(F)(F)F)=C2C)N=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kissell LW, Leavens TL, Baynes RE, Riviere JE, Smith GW. Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis. J Am Vet Med Assoc. 2015 Jan 1;246(1):118-25. doi: 10.2460/javma.246.1.118. PubMed PMID: 25517334. 2: Smith DJ, Shelver WL, Baynes RE, Tell L, Gehring R, Li M, Dutko T, Schroeder JW, Herges G, Riviere JE. Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows. J Agric Food Chem. 2015 May 20;63(19):4893-901. doi: 10.1021/acs.jafc.5b01509. Epub 2015 May 7. PubMed PMID: 25950946. 3: Kleinhenz MD, Van Engen NK, Gorden PJ, KuKanich B, Rajewski SM, Walsh P, Coetzee JF. The pharmacokinetics of transdermal flunixin meglumine in Holstein calves. J Vet Pharmacol Ther. 2016 Dec;39(6):612-615. doi: 10.1111/jvp.12314. Epub 2016 Apr 28. PubMed PMID: 27121728. 4: Marini D, Pippia J, Colditz IG, Hinch GN, Petherick CJ, Lee C. Palatability and pharmacokinetics of flunixin when administered to sheep through feed. PeerJ. 2016 Mar 14;4:e1800. doi: 10.7717/peerj.1800. eCollection 2016. PubMed PMID: 26989633; PubMed Central PMCID: PMC4793306. 5: Kissell LW, Brinson PD, Gehring R, Tell LA, Wetzlich SE, Baynes RE, Riviere JE, Smith GW. Pharmacokinetics and tissue elimination of flunixin in veal calves. Am J Vet Res. 2016 Jun;77(6):634-40. doi: 10.2460/ajvr.77.6.634. PubMed PMID: 27227502. 6: Shelver WL, Smith DJ, Tell LA, Baynes RE, Schroeder JW, Riviere JE. Screening and Confirmatory Analyses of Flunixin in Tissues and Bodily Fluids after Intravenous or Intramuscular Administration to Cull Dairy Cows with or without Lipopolysaccharide Challenge. J Agric Food Chem. 2016 Jan 13;64(1):336-45. doi: 10.1021/acs.jafc.5b04793. Epub 2015 Dec 22. PubMed PMID: 26695354. 7: Pairis-Garcia MD, Johnson AK, Abell CA, Coetzee JF, Karriker LA, Millman ST, Stalder KJ. Measuring the efficacy of flunixin meglumine and meloxicam for lame sows using a GAITFour pressure mat and an embedded microcomputer-based force plate system. J Anim Sci. 2015 May;93(5):2100-10. doi: 10.2527/jas.2014-8796. PubMed PMID: 26020306. 8: Shelver WL, Schneider MJ, Smith DJ. Distribution of Flunixin Residues in Muscles of Dairy Cattle Dosed with Lipopolysaccharide or Saline and Treated with Flunixin by Intravenous or Intramuscular Injection. J Agric Food Chem. 2016 Dec 28;64(51):9697-9701. doi: 10.1021/acs.jafc.6b04792. Epub 2016 Dec 13. PubMed PMID: 27958751. 9: El-Hewaity M. Influence of flunixin on the disposition kinetic of cefepime in goats. Adv Pharmacol Sci. 2014;2014:471517. doi: 10.1155/2014/471517. Epub 2014 May 5. PubMed PMID: 24883058; PubMed Central PMCID: PMC4026918. 10: Gopu B, Dileep R, Rani MU, Kumar CS, Kumar MV, Reddy AG. Protective Role of Curcumin and Flunixin Against Acetic Acid-Induced Inflammatory Bowel Disease via Modulating Inflammatory Mediators and Cytokine Profile in Rats. J Environ Pathol Toxicol Oncol. 2015;34(4):309-20. PubMed PMID: 26756424. 11: Duz M, Parkin TD, Cullander RM, Marshall JF. Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery. Am J Vet Res. 2015 Mar;76(3):208-15. doi: 10.2460/ajvr.76.3.208. PubMed PMID: 25710756. 12: Jedziniak P, Olejnik M, Szprengier-Juszkiewicz T, Smulski S, Kaczmarowski M, Żmudzki J. Identification of flunixin glucuronide and depletion of flunixin and its marker residue in bovine milk. J Vet Pharmacol Ther. 2013 Dec;36(6):571-5. doi: 10.1111/jvp.12035. Epub 2013 Feb 11. PubMed PMID: 23398483. 13: Leavens TL, Tell LA, Kissell LW, Smith GW, Smith DJ, Wagner SA, Shelver WL, Wu H, Baynes RE, Riviere JE. Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(9):1506-21. doi: 10.1080/19440049.2014.938363. Epub 2014 Aug 1. PubMed PMID: 25082521. 14: Kissell LW, Baynes RE, Riviere JE, Smith GW. Occurrence of flunixin residues in bovine milk samples from the USA. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(9):1513-6. doi: 10.1080/19440049.2013.803604. Epub 2013 Jun 21. PubMed PMID: 23789859. 15: Zorrilla I, Martinez R, Taggart MA, Richards N. Suspected flunixin poisoning of a wild Eurasian Griffon Vulture from Spain. Conserv Biol. 2015 Apr;29(2):587-92. doi: 10.1111/cobi.12417. Epub 2014 Oct 9. PubMed PMID: 25303011. 16: Thiry J, González-Martín JV, Elvira L, Pagot E, Voisin F, Lequeux G, Weingarten A, de Haas V. Treatment of naturally occurring bovine respiratory disease in juvenile calves with a single administration of a florfenicol plus flunixin meglumine formulation. Vet Rec. 2014 Apr 26;174(17):430. doi: 10.1136/vr.102017. Epub 2014 Mar 6. PubMed PMID: 24603464. 17: Marini D, Pippia J, Colditz IG, Hinch G, Petherick JC, Lee C. Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. Aust Vet J. 2015 Aug;93(8):265-70. doi: 10.1111/avj.12351. PubMed PMID: 26220318. 18: Wu H, Baynes RE, Tell LA, Riviere JE. Prediction of flunixin tissue residue concentrations in livers from diseased cattle. Food Chem Toxicol. 2013 Dec;62:876-9. PubMed PMID: 24416775. 19: Szentkereszty Z, Kotan R, Kiss F, Klarik Z, Posan J, Furka I, Sapy P, Miko I, Peto K, Nemeth N. Effects of various drugs (flunixin, pentoxifylline, enoxaparin) modulating micro-rheological changes in cerulein-induced acute pancreatitis in the rat. Clin Hemorheol Microcirc. 2014;57(4):303-14. doi: 10.3233/CH-131674. PubMed PMID: 23364024. 20: Lee CD, Maxwell LK. Effect of body weight on the pharmacokinetics of flunixin meglumine in miniature horses and quarter horses. J Vet Pharmacol Ther. 2014 Feb;37(1):35-42. doi: 10.1111/jvp.12056. Epub 2013 May 10. PubMed PMID: 23659780.