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MedKoo Cat#: 461237 | Name: Flunixin meglumine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flunixin meglumine is a nonsteroidal anti-inflammatory drug used in many species for pain management

Chemical Structure

Flunixin meglumine
Flunixin meglumine
CAS#42461-84-7 (meglumine)

Theoretical Analysis

MedKoo Cat#: 461237

Name: Flunixin meglumine

CAS#: 42461-84-7 (meglumine)

Chemical Formula: C21H28F3N3O7

Exact Mass: 491.1879

Molecular Weight: 491.46

Elemental Analysis: C, 51.32; H, 5.74; F, 11.60; N, 8.55; O, 22.79

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 550.00 2 Weeks
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Related CAS #
38677-85-9 (free acid) 42461-84-7 (meglumine)
Synonym
Flunixin meglumine; Banamine; Flumeglumine; Flunixin-S; SCH 14714 meglumine; SCH14714 meglumine; SCH-14714 meglumine; NSC-759583; NSC759583; NSC 759583
IUPAC/Chemical Name
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate
InChi Key
MGCCHNLNRBULBU-WZTVWXICSA-N
InChi Code
InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
SMILES Code
O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 491.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cetin Y, Kocamuftuoglu M, Ozyurtlu N, Kucukaslan I, Sendag S, Wehrend A. Effect of flunixin meglumine or prostaglandin E2 treatment 15 days after breeding on fertility in Saanen does. Theriogenology. 2014 Feb;81(3):424-7. doi: 10.1016/j.theriogenology.2013.10.015. Epub 2013 Oct 27. PubMed PMID: 24238401. 2: Kleinhenz MD, Van Engen NK, Gorden PJ, KuKanich B, Rajewski SM, Walsh P, Coetzee JF. The pharmacokinetics of transdermal flunixin meglumine in Holstein calves. J Vet Pharmacol Ther. 2016 Dec;39(6):612-615. doi: 10.1111/jvp.12314. Epub 2016 Apr 28. PubMed PMID: 27121728. 3: Duz M, Parkin TD, Cullander RM, Marshall JF. Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery. Am J Vet Res. 2015 Mar;76(3):208-15. doi: 10.2460/ajvr.76.3.208. PubMed PMID: 25710756. 4: Yilmaz O, Korkmaz M, Jaroszewski JJ, Yazici E, Ulutas E, Saritas ZK. Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches. Pol J Vet Sci. 2014;17(3):493-9. PubMed PMID: 25286659. 5: Lee CD, Maxwell LK. Effect of body weight on the pharmacokinetics of flunixin meglumine in miniature horses and quarter horses. J Vet Pharmacol Ther. 2014 Feb;37(1):35-42. doi: 10.1111/jvp.12056. Epub 2013 May 10. PubMed PMID: 23659780. 6: Pairis-Garcia MD, Johnson AK, Abell CA, Coetzee JF, Karriker LA, Millman ST, Stalder KJ. Measuring the efficacy of flunixin meglumine and meloxicam for lame sows using a GAITFour pressure mat and an embedded microcomputer-based force plate system. J Anim Sci. 2015 May;93(5):2100-10. doi: 10.2527/jas.2014-8796. PubMed PMID: 26020306. 7: Howard JT, O'Nan AT, Maltecca C, Baynes RE, Ashwell MS. Differential Gene Expression across Breed and Sex in Commercial Pigs Administered Fenbendazole and Flunixin Meglumine. PLoS One. 2015 Sep 14;10(9):e0137830. doi: 10.1371/journal.pone.0137830. eCollection 2015. PubMed PMID: 26366864; PubMed Central PMCID: PMC4569569. 8: Thiry J, González-Martín JV, Elvira L, Pagot E, Voisin F, Lequeux G, Weingarten A, de Haas V. Treatment of naturally occurring bovine respiratory disease in juvenile calves with a single administration of a florfenicol plus flunixin meglumine formulation. Vet Rec. 2014 Apr 26;174(17):430. doi: 10.1136/vr.102017. Epub 2014 Mar 6. PubMed PMID: 24603464. 9: Pairis-Garcia MD, Karriker LA, Johnson AK, Kukanich B, Wulf L, Sander S, Millman ST, Stalder KJ, Coetzee JF. Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration. BMC Vet Res. 2013 Aug 13;9:165. doi: 10.1186/1746-6148-9-165. PubMed PMID: 23941181; PubMed Central PMCID: PMC3751365. 10: Musser JM, Heatley JJ, Phalen DN. Pharmacokinetics after intravenous administration of flunixin meglumine in budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). J Am Vet Med Assoc. 2013 Jan 15;242(2):205-8. doi: 10.2460/javma.242.2.205. PubMed PMID: 23276097. 11: Huber J, Arnholdt T, Möstl E, Gelfert CC, Drillich M. Pain management with flunixin meglumine at dehorning of calves. J Dairy Sci. 2013 Jan;96(1):132-40. doi: 10.3168/jds.2012-5483. Epub 2012 Nov 22. PubMed PMID: 23182358. 12: Smith DJ, Shelver WL, Baynes RE, Tell L, Gehring R, Li M, Dutko T, Schroeder JW, Herges G, Riviere JE. Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows. J Agric Food Chem. 2015 May 20;63(19):4893-901. doi: 10.1021/acs.jafc.5b01509. Epub 2015 May 7. PubMed PMID: 25950946. 13: Miciletta M, Cuniberti B, Barbero R, Re G. In vitro enantioselective pharmacodynamics of Carprofen and Flunixin-meglumine in feedlot cattle. J Vet Pharmacol Ther. 2014 Feb;37(1):43-52. doi: 10.1111/jvp.12052. Epub 2013 Apr 25. PubMed PMID: 23614639. 14: Burkett BN, Thomason JM, Hurdle HM, Wills RW, Fontenot RL. Effects of Firocoxib, Flunixin Meglumine, and Phenylbutazone on Platelet Function and Thromboxane Synthesis in Healthy Horses. Vet Surg. 2016 Nov;45(8):1087-1094. doi: 10.1111/vsu.12567. Epub 2016 Oct 12. PubMed PMID: 27731498. 15: Naylor RJ, Taylor AH, Knowles EJ, Wilford S, Linnenkohl W, Mair TS, Johns IC. Comparison of flunixin meglumine and meloxicam for post operative management of horses with strangulating small intestinal lesions. Equine Vet J. 2014 Jul;46(4):427-34. doi: 10.1111/evj.12224. Epub 2014 Feb 18. PubMed PMID: 24372991. 16: Deyrup CL, Southern KJ, Cornett JA, Shultz CE, Cera DA. Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey. J Am Vet Med Assoc. 2012 Jul 15;241(2):249-53. doi: 10.2460/javma.241.2.249. PubMed PMID: 22765373. 17: Geary TW. Effects of adrenocorticotropic hormone and flunixin meglumine on pregnancy retention in beef cows. J Anim Sci. 2012 Jan;90(1):207-11. doi: 10.2527/jas.2010-3564. Epub 2011 Aug 19. PubMed PMID: 21856895. 18: Kim SS, Bang JI, Fakruzzaman M, Lee KL, Ko DH, Ghanem N, Wang Z, Kong IK. Effects of flunixin meglumine and prostaglandin F2 α treatments on the development and quality of bovine embryos in vitro. Reprod Domest Anim. 2014 Dec;49(6):957-63. doi: 10.1111/rda.12413. Epub 2014 Sep 24. PubMed PMID: 25251522. 19: Coble DJ, Taylor DK, Mook DM. Analgesic effects of meloxicam, morphine sulfate, flunixin meglumine, and xylazine hydrochloride in African-clawed frogs (Xenopus laevis). J Am Assoc Lab Anim Sci. 2011 May;50(3):355-60. PubMed PMID: 21640031; PubMed Central PMCID: PMC3103286. 20: Knych HK, Arthur RM, McKemie DS, Chapman N. Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses. J Vet Pharmacol Ther. 2015 Aug;38(4):313-20. doi: 10.1111/jvp.12197. Epub 2015 Jan 13. PubMed PMID: 25582761.

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FGF2-IN-21

FGF2-IN-21