Scandenolide | CAS#23758-16-9 | sesquiterpene lactone

MedKoo Cat#: 461903 | Name: Scandenolide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scandenolide is a sesquiterpene lactone isolated from the Philippines medicinal plant Mikania cordata.

Chemical Structure

Scandenolide

CAS#23758-16-9

Theoretical Analysis

MedKoo Cat#: 461903

Name: Scandenolide

CAS#: 23758-16-9

Chemical Formula: C17H24O5

Exact Mass: 308.1624

Molecular Weight: 308.37

Elemental Analysis: C, 66.21; H, 7.85; O, 25.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Scandenolide;

IUPAC/Chemical Name

(1aS,3S,6S,6aS,9aR,10aR,E)-4,6,10a-trimethyl-8-oxo-1a,2,3,6,6a,7,8,9a,10,10a-decahydrooxireno[2',3':8,9]cyclodeca[1,2-b]furan-3-yl acetate

InChi Key

AQWQAHKPDYJISF-RMNCBRABSA-N

InChi Code

InChI=1S/C17H24O5/c1-9-5-10(2)13(20-11(3)18)7-15-17(4,22-15)8-14-12(9)6-16(19)21-14/h5,9,12-15H,6-8H2,1-4H3/b10-5+/t9-,12-,13-,14+,15-,17+/m0/s1

SMILES Code

C/C1=C\[C@@H]([C@@H]2CC(O[C@@H]2C[C@]3(C)[C@H](C[C@@H]1OC(C)=O)O3)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 308.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ysrael MC, Croft KD. Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. Planta Med. 1990 Jun;56(3):268-70. PubMed PMID: 2168055. 2: Li Y, Li J, Li Y, Wang XX, Cao AC. Antimicrobial constituents of the leaves of Mikania micrantha H. B. K. PLoS One. 2013 Oct 2;8(10):e76725. doi: 10.1371/journal.pone.0076725. eCollection 2013. PubMed PMID: 24098556; PubMed Central PMCID: PMC3788719. 3: Ahmed M, Rahman MT, Alimuzzaman M, Shilpi JA. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001 Dec;72(8):919-21. PubMed PMID: 11731117. 4: Laurella LC, Cerny N, Bivona AE, Sánchez Alberti A, Giberti G, Malchiodi EL, Martino VS, Catalan CA, Alonso MR, Cazorla SI, Sülsen VP. Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp. PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005929. doi: 10.1371/journal.pntd.0005929. eCollection 2017 Sep. PubMed PMID: 28945741; PubMed Central PMCID: PMC5629014.