IUPAC/Chemical Name
4,4-Diphenyl-N-isopropylcyclohexylamine hydrochloride
InChi Key
BMBNXHMQMNPCIV-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27N.ClH/c1-17(2)22-20-13-15-21(16-14-20,18-9-5-3-6-10-18)19-11-7-4-8-12-19;/h3-12,17,20,22H,13-16H2,1-2H3;1H
SMILES Code
CC(NC1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)CC1)C.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Pramiverin HCl is a bioactive chemical.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.91
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Carrillo Mancero LA. Pramiverina-metamizol (1): nueva fórmula para el control del cólico de origen digestivo [Pramiverin-metamizole: new formula for the control of colic of gastrointestinal origin]. G E N. 1977 Apr-Jun;31(4):421-6. Spanish. PMID: 97151.
2: Romero HE, Fernández AC, Rosales TC. Wirkung der Kombination Pramiverin/Metamizol bei kolikartigen Schmerzzuständen [The effect of the combination pramiverine/metamizole in colic pain (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):738-40. German. PMID: 989023.
3: Niemann H, Jakob G. Oesophagusmanometrische Befunde beim Menschen nach intravenöser Applikation eines neuen Cholinolytikums (Pramiverin), von Atropin und von Scopolamin-butylbromid [Eosphagomanometric finding in man after intravenous administration of a new cholinolytic (pramiverine), atropine and scopolamine butylbromide]. Arzneimittelforschung. 1976 Apr;26(4b):728-30. German. PMID: 989022.
4: Diekmann HW. Gaschromatographische Bestimmung von Pramiverin in Körperflüssigkeiten [Gaschromatographic determination of pramiverine in body fluids (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):727-8. German. PMID: 989021.
5: Steiner K, Garbe A. Organverteilung von 14C-Pramiverin im Organismus der Ratte [Organ distribution of 14C-pramiverine in the rat]. Arzneimittelforschung. 1976 Apr;26(4b):709-16. German. PMID: 989020.
6: Eberstein M, Frohberg H, Hofmann A, Jochmann G, Metallinos A, Schiling B, Weisse G. Toxikologische Prüfung von Pramiverin [Toxicological study on pramiverine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):703-9. German. PMID: 989019.
7: Morel CJ. Experimentelle Untersuchungen mit Pramiverin [Experimental studies on pramiverine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):699-702. German. PMID: 989018.
8: Chieri RA. Tierexperimentelle Untersuchungen auf spasmolytische und analgetische Wirkungen von Pramiverin, Metamizol sowie einer Kombination beider Substanzen [Animal experimental study on spasmolytic and analgesic activities of pramiverine, metamizole and their combination (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):696-8. German. PMID: 989017.
9: Diekmann HW, Bühring KU, Garbe A, Nowak H. Metabolismus von Pramiverin [Metabolism of pramiverine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):722-6. German. PMID: 821495.
10: Steiner K, Diekmann HW, Garbe A, Nowak H. Pharmakokinetik von Pramiverin bei Ratten, Hunden and Rhesus-Affen [Pharmacokinetics of pramiverine in rats, dogs, and monkeys (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):717-21. German. PMID: 821494.
11: Enenkel HJ, Müller-Calgan H, Schorscher E. Zur cholinolytischen Wirkung von Pramiverin [On the cholinolytic activity of pramiverine]. Arzneimittelforschung. 1976 Apr;26(4b):690-6. German. PMID: 821493.
12: Koch E, Eisele W. Therapieergebnisse mit der Kombination Pramiverin/metamizol in einem Feldversuch [Therapeutic results with the combination pramiverine/metamizole in a multicentre trial (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):745-52. German. PMID: 782472.
13: Toledo GM. Prüfung eines neuen Spasmolytikums, Pramiverin, in seiner Wirkung auf die Kolitis [Clinical trial of a novel spasmolytic, pramiverine, and its influence in colitis (author's transl]. Arzneimittelforschung. 1976 Apr;26(4b):731-2. German. PMID: 782470.
14: Koch E. Zusammenfassung der Ergebnisse klinischer und experimenteller Untersuchungen mit Pramiverin und Pramiverin/Metamizol [Profile comment on clinical and experimental studies of pramiverine and pramiverine/metamizole (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4b):686-9. German. PMID: 782469.
15: Morel CJ. Empleo del anticolinérgico y antiespasmódico pramiverin (HSp 2986, E. Merck) para obtener vagotomía médica [Use of the anticholinergic and antispasmodic agent pramiverin (HSp 2986, E. Merck) to obtain medical vagotomy]. Rev Esp Enferm Apar Dig. 1974 Jan 1;42(1):73-80. Spanish. PMID: 4460118.
