IUPAC/Chemical Name
1,3,5-Triazine-2,4-diamine, N-(4-chlorophenyl)- (9CI)
InChi Key
YRZQHIVOIFJEEE-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H8ClN5/c10-6-1-3-7(4-2-6)14-9-13-5-12-8(11)15-9/h1-5H,(H3,11,12,13,14,15)
SMILES Code
NC1=NC=NC(NC2=CC=C(Cl)C=C2)=N1
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
221.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Thevis M, Krug O, Geyer H, Walpurgis K, Baume N, Thomas A. Analytical challenges in sports drug testing. Anal Bioanal Chem. 2018 Mar;410(9):2275-2281. doi: 10.1007/s00216-018-0934-9. Epub 2018 Feb 14. PubMed PMID: 29445832.
2: Thevis M, Geyer H, Thomas A, Tretzel L, Bailloux I, Buisson C, Lasne F, Schaefer MS, Kienbaum P, Mueller-Stoever I, Schänzer W. Formation of the diuretic chlorazanil from the antimalarial drug proguanil--implications for sports drug testing. J Pharm Biomed Anal. 2015 Nov 10;115:208-13. doi: 10.1016/j.jpba.2015.07.017. Epub 2015 Jul 22. PubMed PMID: 26226108.
3: Pommer W, Offermann G, Schultze G, Krause PH, Molzahn M. [Acute interstitial nephritis caused by drugs]. Dtsch Med Wochenschr. 1983 May 20;108(20):783-8. German. PubMed PMID: 6840011.
4: Olsen UB. Investigation of the role of kidney kallikrein on bumetanide induced diuresis in rats. Acta Pharmacol Toxicol (Copenh). 1981 Nov;49(5):321-6. PubMed PMID: 6179386.
5: Olsen UB, Eilertsen E. Reduced urine kallikrein excretion and antikaliuresis by chlorazanil in rats. Acta Pharmacol Toxicol (Copenh). 1981 Sep;49(3):210-4. PubMed PMID: 6917682.
6: Olsen UB. Dissociation between renal medullary PGE2-synthesis and urine PGE2-excretion. Antagonism by bumetanide of chlorazanil induced urine PGE2-excretion in rats. Prostaglandins. 1981 Apr;21(4):591-7. PubMed PMID: 7255744.
7: Olsen UB, Eilertsen E, Arrigoni-Martelli E. Enhancement of urinary prostaglandin excretion by chlorazanil in rats. Effects of indomethacin. Acta Pharmacol Toxicol (Copenh). 1980 Oct;47(4):263-6. PubMed PMID: 7468226.
8: Olsen UB, Ahnfelt-Rønne I. Enhancement of urine prostaglandin excretion by chlorazanil in dogs. Acta Pharmacol Toxicol (Copenh). 1978 Sep;43(3):233-9. PubMed PMID: 707136.
9: Hyde TA, Davis JC. The effects of cortisol and chlorazanil on the mitotic rate in mouse liver and skin. Eur J Cancer. 1966 Aug;2(3):227-30. PubMed PMID: 5974758.
10: GRILLMAIER H. [The effect of a combined administration of maximum effective doses of chlorazanil and hydrochlorothiazide on sodium excretion in anesthetized rats]. Arzneimittelforschung. 1962 May;12:503-7. German. PubMed PMID: 13901931.
11: GRILLMAIER H. [The diuretic effect of chlorazanil in rats deprived of food and water]. Arzneimittelforschung. 1961 Apr;11:350-3. German. PubMed PMID: 13708685.
12: KUEHN G. [The effects of N-p-chlorophenyl-2,4-diamino-s-triazine HC1 (triazurol, Orpidan) and 1-allyl-3-ethyl-6-aminouracil (Katapyrin) on renal phosphate excretion]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1961;241:175-6. German. PubMed PMID: 13754864.
13: GOERES E, JUNG F. [On the modification of acetazolamide-and chlorazanil-induced rats after chronic pretreatment with chlorothiazide]. Acta Biol Med Ger. 1961;6:35-42. German. PubMed PMID: 13706252.
14: KUPKE D. [Experimental animal research on the subchronic toxicity of chlorazanil]. Dtsch Gesundheitsw. 1960 Jul 14;15:1456-63. German. PubMed PMID: 13755226.
15: HASS HD. [Experiences with the diuretic, triazurol in glaucoma therapy]. Dtsch Gesundheitsw. 1959 Oct 15;14:1942-3. German. PubMed PMID: 13851972.
16: FORD RV, ROCHELLE JB 3rd, BULLOCK AC, SPURR CL, HANDLEY C, MOYER JH. Laboratory and clinical observations on chlorazanil, a nonmercurial orally effective diuretic agent. Am J Cardiol. 1959 Feb;3(2):148-61. PubMed PMID: 13626844.
17: ERSHOFF BH. Beneficial effects of alfalfa meal on chlorazanil hydrochloride toxicity in the rat. Exp Med Surg. 1959;17:204-9. PubMed PMID: 13820705.
