Synonym
Chlordane; CD68; CD-68; CD 68
IUPAC/Chemical Name
(4S,7R)-1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoindene
InChi Key
BIWJNBZANLAXMG-YQELWRJZSA-N
InChi Code
InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2/t2?,3?,4?,5?,8-,9+/m0/s1
SMILES Code
ClC1CC2C([C@]3(C(Cl)=C([C@@]2(C3(Cl)Cl)Cl)Cl)Cl)C1Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
409.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chlordane. IARC Monogr Eval Carcinog Risk Chem Hum. 1979 Oct;20:45-65. PMID: 397174.
2: Chlordane. Rev Environ Contam Toxicol. 1988;104:47-62. doi: 10.1007/978-1-4613-8785-5_5. PMID: 3062701.
3: Chlordane and heptachlor. IARC Monogr Eval Carcinog Risks Hum. 1991;53:115-75. PMID: 1842578.
4: Singh K, Nong A, Feeley M, Chan HM. Development of Biomonitoring Equivalents for chlordane and toxaphene with application to the general Canadian population. Regul Toxicol Pharmacol. 2019 Aug;106:262-269. doi: 10.1016/j.yrtph.2019.05.015. Epub 2019 May 16. PMID: 31103637.
5: Byard JL, Paulsen SC, Tjeerdema RS, Chiavelli D. DDT, chlordane, toxaphene and PCB residues in Newport Bay and Watershed: assessment of hazard to wildlife and human health. Rev Environ Contam Toxicol. 2015;235:49-168. doi: 10.1007/978-3-319-10861-2_3. PMID: 25376114.
6: Grutsch JF, Khasawinah A. Signs and mechanisms of chlordane intoxication. Biomed Environ Sci. 1991 Sep;4(3):317-26. PMID: 1764223.
7: Wang D, Wang X, Zhang P, Wang Y, Zhang R, Yan J, Zhou Z, Zhu W. The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen. Environ Pollut. 2017 Mar;222:532-542. doi: 10.1016/j.envpol.2016.11.028. Epub 2016 Dec 29. PMID: 28041837.
8: Mattina MJ, Iannucci-Berger W, Dykas L. Chlordane uptake and its translocation in food crops. J Agric Food Chem. 2000 May;48(5):1909-15. doi: 10.1021/jf990566a. PMID: 10820114.
9: Kania-Korwel I, Lehmler HJ. Chlordane and heptachlor are metabolized enantioselectively by rat liver microsomes. Environ Sci Technol. 2013 Aug 6;47(15):8913-22. doi: 10.1021/es401916a. Epub 2013 Jul 10. PMID: 23799267; PMCID: PMC3748599.
10: Xiao P, Mori T, Kondo R. Biotransformation of the organochlorine pesticide trans-chlordane by wood-rot fungi. N Biotechnol. 2011 Dec 15;29(1):107-15. doi: 10.1016/j.nbt.2011.06.013. Epub 2011 Jun 28. PMID: 21718811.
