2-Furoic acid | CAS#88-14-2 | heterocyclic carboxylic acid

MedKoo Cat#: 558613 | Name: 2-Furoic acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-Furoic acid is a heterocyclic carboxylic acid that is shown to be effective in lowering both serum cholesterol and serum triglyceride levels significantly in rats with an elevation of HDL cholesterol level at 20 mg/kg/day orally.

Chemical Structure

2-Furoic acid

CAS#88-14-2

Theoretical Analysis

MedKoo Cat#: 558613

Name: 2-Furoic acid

CAS#: 88-14-2

Chemical Formula: C5H4O3

Exact Mass: 112.0200

Molecular Weight: 112.08

Elemental Analysis: C, 53.58; H, 3.60; O, 42.82

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

2-Furoic acid; 2 Furoic acid; 2Furoic acid; alpha-Furancarboxylic acid; alpha-Furoic acid; Kyselina 2-furoova;

IUPAC/Chemical Name

2-Furancarboxylic acid

InChi Key

SMNDYUVBFMFKNZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)

SMILES Code

O=C(C1=CC=CO1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 112.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ghalla H, Issaoui N, Castillo MV, Brandán SA, Flakus HT. A complete assignment of the vibrational spectra of 2-furoic acid based on the structures of the more stable monomer and dimer. Spectrochim Acta A Mol Biomol Spectrosc. 2014;121:623-31. doi: 10.1016/j.saa.2013.11.001. Epub 2013 Nov 11. PubMed PMID: 24291575. 2: COGGIOLA IM. 2,5-DIHYDRO-2-FUROIC ACID: A PRODUCT OF THE ANAEROBIC DECOMPOSITION OF ASCORBIC ACID. Nature. 1963 Dec 7;200:954-5. PubMed PMID: 14097741. 3: Balachandran V, Rajeswari S, Lalitha S. Vibrational spectra, NBO analysis, first order hyperpolarizabilities, thermodynamic functions and NMR chemical shielding anisotropy (CSA) parameters of 5-nitro-2-furoic acid by ab initio HF and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;113:268-80. doi: 10.1016/j.saa.2013.04.053. Epub 2013 Apr 19. PubMed PMID: 23735205. 4: KAKINUMA A, YAMATODANI S. L-GLUTAMIC ACID FORMATION FROM 2-FUROIC ACID BY SOIL BACTERIA. Nature. 1964 Jan 25;201:420-1. PubMed PMID: 14110024. 5: Hall IH, Wong OT, Reynolds DJ, Chang JJ. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23. PubMed PMID: 8447721. 6: LAURENT-JARDILLIER C, LEVY J, MICHEL-BER E. [Relations between the chemical structure, negative bathmotropic properties, local anesthetic properties and anticholinergic properties of some derivatives of 2-furoic acid]. Therapie. 1958;13(5):769-91. French. PubMed PMID: 13625190. 7: Tan ZB, Tonks CE, O'Donnell GE, Geyer R. An improved HPLC analysis of the metabolite furoic acid in the urine of workers occupationally exposed to furfural. J Anal Toxicol. 2003 Jan-Feb;27(1):43-6. PubMed PMID: 12587683. 8: Aaron CS, Harbach PR, Wiser SK, Grzegorczyk CR, Smith AL. The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: evaluation of 2-furoic acid and 7 drug candidates. Mutat Res. 1989 Jun;223(2):163-9. PubMed PMID: 2739679. 9: Abdelhamid HN, Wu HF. Furoic and mefenamic acids as new matrices for matrix assisted laser desorption/ionization-(MALDI)-mass spectrometry. Talanta. 2013 Oct 15;115:442-50. doi: 10.1016/j.talanta.2013.05.050. Epub 2013 May 28. PubMed PMID: 24054616. 10: Nichols NN, Mertens JA. Identification and transcriptional profiling of Pseudomonas putida genes involved in furoic acid metabolism. FEMS Microbiol Lett. 2008 Jul;284(1):52-7. doi: 10.1111/j.1574-6968.2008.01196.x. Epub 2008 May 17. PubMed PMID: 18492059. 11: Pacheco JJ, Davis ME. Synthesis of terephthalic acid via Diels-Alder reactions with ethylene and oxidized variants of 5-hydroxymethylfurfural. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8363-7. doi: 10.1073/pnas.1408345111. Epub 2014 May 27. PubMed PMID: 24912153; PubMed Central PMCID: PMC4060660. 12: Zhang S, Winestrand S, Chen L, Li D, Jönsson LJ, Hong F. Tolerance of the nanocellulose-producing bacterium Gluconacetobacter xylinus to lignocellulose-derived acids and aldehydes. J Agric Food Chem. 2014 Oct 8;62(40):9792-9. doi: 10.1021/jf502623s. Epub 2014 Sep 16. PubMed PMID: 25186182. 13: Yanagita H, Urano E, Matsumoto K, Ichikawa R, Takaesu Y, Ogata M, Murakami T, Wu H, Chiba J, Komano J, Hoshino T. Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase. Bioorg Med Chem. 2011 Jan 15;19(2):816-25. doi: 10.1016/j.bmc.2010.12.011. Epub 2010 Dec 9. PubMed PMID: 21193314. 14: Elmore CS, Landvatter S, Dorff PN, Powell ME, Killick D, Blake T, Hall J, Heys JR, Harding J, Urbanek R, Ernst G. Synthesis of three alpha 7 agonists in labeled form. J Labelled Comp Radiopharm. 2014 May 15;57(5):342-9. doi: 10.1002/jlcr.3186. Epub 2014 Apr 4. PubMed PMID: 24700683. 15: Tsuge Y, Hori Y, Kudou M, Ishii J, Hasunuma T, Kondo A. Detoxification of furfural in Corynebacterium glutamicum under aerobic and anaerobic conditions. Appl Microbiol Biotechnol. 2014 Oct;98(20):8675-83. doi: 10.1007/s00253-014-5924-z. Epub 2014 Aug 13. PubMed PMID: 25112225. 16: Liu D, Pozharski E, Fu M, Silverman RB, Ringe D. Mechanism of inactivation of Escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid . Biochemistry. 2010 Dec 14;49(49):10507-15. doi: 10.1021/bi101325z. Epub 2010 Nov 15. PubMed PMID: 21033689; PubMed Central PMCID: PMC3013228. 17: Fabregat V, Burguete MI, Galindo F, Luis SV. Singlet oxygen generation by photoactive polymeric microparticles with enhanced aqueous compatibility. Environ Sci Pollut Res Int. 2014 Oct;21(20):11884-92. doi: 10.1007/s11356-013-2311-8. Epub 2013 Nov 24. PubMed PMID: 24271726. 18: Vlahov A, Volf D. Poikilothermia induced by a 2-furancarboxylic acid derivative. Pharmazie. 2000 May;55(5):396-7. PubMed PMID: 11828627. 19: Zhang Y, Huang B, Zhao Z, Zhou Y. [Study on the chemical constituents from the ethyl acetate extracts of Cremastra appendiculata]. Zhong Yao Cai. 2011 Dec;34(12):1882-3. Chinese. PubMed PMID: 22500423. 20: Banerjee A, Dick GR, Yoshino T, Kanan MW. Carbon dioxide utilization via carbonate-promoted C-H carboxylation. Nature. 2016 Mar 10;531(7593):215-9. doi: 10.1038/nature17185. PubMed PMID: 26961655.