Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
MedKoo Cat#: 558607
Name: Pibrozelesin
CAS#: 154889-68-6 (free base)
Chemical Formula: C32H36BrN5O8
Exact Mass: 697.1700
Molecular Weight: 698.57
Elemental Analysis: C, 55.02; H, 5.19; Br, 11.44; N, 10.03; O, 18.32
The following data is based on the product molecular weight 698.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
