Lefucoxib | CAS#849048-84-6 | COX-2 inhibitor

MedKoo Cat#: 563671 | Name: Lefucoxib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lefucoxib is a cyclooxygenase-2 (COX-2) inhibitor.

Chemical Structure

Lefucoxib

CAS#849048-84-6

Theoretical Analysis

MedKoo Cat#: 563671

Name: Lefucoxib

CAS#: 849048-84-6

Chemical Formula: C19H17F3N2O2S

Exact Mass: 394.0963

Molecular Weight: 394.41

Elemental Analysis: C, 57.86; H, 4.34; F, 14.45; N, 7.10; O, 8.11; S, 8.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lefucoxib;

IUPAC/Chemical Name

1-[4-(Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(3,4-dimethylphenyl)pyrazole

InChi Key

BYPOBZCPKWLRFH-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17F3N2O2S/c1-12-4-5-14(10-13(12)2)17-11-18(19(20,21)22)23-24(17)15-6-8-16(9-7-15)27(3,25)26/h4-11H,1-3H3

SMILES Code

CC1=CC=C(C2=CC(C(F)(F)F)=NN2C3=CC=C(S(=O)(C)=O)C=C3)C=C1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 394.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bi X, Meng Z, Chen H, Zhu X, Dou G. In vivo and in vitro metabolism of lefucoxib in rats. J Pharm Biomed Anal. 2008 Sep 10;48(1):134-9. doi: 10.1016/j.jpba.2008.04.024. Epub 2008 Apr 30. PubMed PMID: 18538525. 2: Bi X, Meng Z, Dou G. Determination of lefucoxib in rat plasma, urine, and feces by high-performance liquid chromatography with fluorescence detection: application in pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):199-205. Epub 2006 Dec 11. PubMed PMID: 17161982.