Pongamol | CAS#484-33-3 | Neuroprotectant

MedKoo Cat#: 598272 | Name: Pongamol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pongamol, a flavonoid isolated from Pongamia pinnata, exhibits diverse bioactivities with promising pharmacological potential. It has shown significant anti-inflammatory effects by inhibiting nitric oxide production in LPS-stimulated macrophages (IC₅₀ ≈ 6–10 µM) and downregulating pro-inflammatory cytokines like TNF-α and IL-6. Pongamol also demonstrates anticancer activity, particularly against breast (MCF-7) and liver (HepG2) cancer cell lines, with reported IC₅₀ values ranging from 10 to 25 µM. Additionally, it exhibits antibacterial properties against Staphylococcus aureus and Escherichia coli, and moderate antifungal activity. Molecular docking and in vitro assays further support its role as a potential inhibitor of enzymes such as COX-2 and tyrosinase, underscoring its utility in anti-inflammatory and dermatological applications.

Chemical Structure

Pongamol

CAS#484-33-3

Theoretical Analysis

MedKoo Cat#: 598272

Name: Pongamol

CAS#: 484-33-3

Chemical Formula: C18H14O4

Exact Mass: 294.0892

Molecular Weight: 294.30

Elemental Analysis: C, 73.46; H, 4.80; O, 21.74

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 550.00	2 Weeks
1g	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Pongamol; Lanceolatin C;

IUPAC/Chemical Name

1-(4-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione

InChi Key

XTLSKKJNOIMMBK-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14O4/c1-21-18-13(7-8-17-14(18)9-10-22-17)16(20)11-15(19)12-5-3-2-4-6-12/h2-10H,11H2,1H3

SMILES Code

O=C(C1=CC=C(OC=C2)C2=C1OC)CC(C3=CC=CC=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 294.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tamrakar AK, Jaiswal N, Yadav PP, Maurya R, Srivastava AK. Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells. Mol Cell Endocrinol. 2011 Jun 6;339(1-2):98-104. doi: 10.1016/j.mce.2011.03.023. Epub 2011 Apr 8. PubMed PMID: 21497640. 2: Tamrakar AK, Yadav PP, Tiwari P, Maurya R, Srivastava AK. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. J Ethnopharmacol. 2008 Aug 13;118(3):435-9. doi: 10.1016/j.jep.2008.05.008. Epub 2008 May 15. PubMed PMID: 18572336. 3: Perumalsamy H, Jang MJ, Kim JR, Kadarkarai M, Ahn YJ. Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. Parasit Vectors. 2015 Apr 19;8:237. doi: 10.1186/s13071-015-0848-8. PubMed PMID: 25928224; PubMed Central PMCID: PMC4410478. 4: Sharma R, Vishwakarma RA, Bharate SB. An efficient transformation of furano-hydroxychalcones to furanoflavones via base mediated intramolecular tandem O-arylation and C-O bond cleavage: a new approach for the synthesis of furanoflavones. Org Biomol Chem. 2015 Nov 14;13(42):10461-5. doi: 10.1039/c5ob01802a. Epub 2015 Oct 1. PubMed PMID: 26426474. 5: Lodhi S, Jain A, Jain AP, Pawar RS, Singhai AK. Effects of flavonoids from Martynia annua and Tephrosia purpurea on cutaneous wound healing. Avicenna J Phytomed. 2016 Sep-Oct;6(5):578-591. PubMed PMID: 27761428; PubMed Central PMCID: PMC5052421. 6: Peng Y, Chen Y, Gao C, Yan T, Cao W, Huang R. A new 1,2-ethanedione benzofurane derivative from Tephrosia purpurea. Nat Prod Res. 2014;28(20):1705-8. doi: 10.1080/14786419.2014.940587. Epub 2014 Aug 12. PubMed PMID: 25116833. 7: Rao EV, Sudheer P. Revisiting curcumin chemistry part I: a new strategy for the synthesis of curcuminoids. Indian J Pharm Sci. 2011 May;73(3):262-70. doi: 10.4103/0250-474X.93508. PubMed PMID: 22457548; PubMed Central PMCID: PMC3309644. 8: Magalhães AF, Tozzi AM, Magalhães EG, Sannomiya M, Soriano Mdel P, Perez MA. Flavonoids of Lonchocarpus montanus A.M.G. Azevedo and biological activity. An Acad Bras Cienc. 2007 Sep;79(3):351-67. PubMed PMID: 17768528. 9: Al Muqarrabun LM, Ahmat N, Ruzaina SA, Ismail NH, Sahidin I. Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: a review. J Ethnopharmacol. 2013 Nov 25;150(2):395-420. doi: 10.1016/j.jep.2013.08.041. Epub 2013 Sep 7. Review. PubMed PMID: 24016802. 10: Chang LC, Gerhäuser C, Song L, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. J Nat Prod. 1997 Sep;60(9):869-73. PubMed PMID: 9322358. 11: Ranga Rao R, Tiwari AK, Prabhakar Reddy P, Suresh Babu K, Ali AZ, Madhusudana K, Madhusudana Rao J. New furanoflavanoids, intestinal alpha-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.). Bioorg Med Chem. 2009 Jul 15;17(14):5170-5. doi: 10.1016/j.bmc.2009.05.051. Epub 2009 May 28. PubMed PMID: 19515570.

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PF0998425