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MedKoo Cat#: 584251 | Name: Bombolitin V

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bombolitin V is a mast cell degranulating peptide from the venom of the bumblebee Megabombus pennsylvanicus.

Chemical Structure

Bombolitin V
Bombolitin V
CAS#95648-98-9

Theoretical Analysis

MedKoo Cat#: 584251

Name: Bombolitin V

CAS#: 95648-98-9

Chemical Formula: C81H144N22O19

Exact Mass: 1729.0978

Molecular Weight: 1730.18

Elemental Analysis: C, 56.23; H, 8.39; N, 17.81; O, 17.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Bombolitin V
IUPAC/Chemical Name
L-Leucinamide, L-isoleucyl-L-asparaginyl-L-valyl-L-leucylglycyl-L-isoleucyl-L-leucylglycyl-L-leucyl-L-leucylglycyl-L-lysyl-L-alanyl-L-leucyl-L-seryl-L-histidyl-
InChi Key
IOCWBJCCGSYJPN-SDXYAQEHSA-N
InChi Code
InChI=1S/C81H144N22O19/c1-20-47(17)65(84)79(120)98-59(33-61(83)105)77(118)103-66(46(15)16)80(121)99-54(28-42(7)8)71(112)89-37-64(108)102-67(48(18)21-2)81(122)100-55(29-43(9)10)72(113)88-36-63(107)93-56(30-44(11)12)74(115)96-53(27-41(5)6)70(111)87-35-62(106)92-51(24-22-23-25-82)73(114)91-49(19)69(110)95-57(31-45(13)14)75(116)101-60(38-104)78(119)97-58(32-50-34-86-39-90-50)76(117)94-52(68(85)109)26-40(3)4/h34,39-49,51-60,65-67,104H,20-33,35-38,82,84H2,1-19H3,(H2,83,105)(H2,85,109)(H,86,90)(H,87,111)(H,88,113)(H,89,112)(H,91,114)(H,92,106)(H,93,107)(H,94,117)(H,95,110)(H,96,115)(H,97,119)(H,98,120)(H,99,121)(H,100,122)(H,101,116)(H,102,108)(H,103,118)/t47-,48-,49-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,65-,66-,67-/m0/s1
SMILES Code
CC(C)C[C@@H](C(N)=O)NC([C@H](CC1=CNC=N1)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,730.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Argiolas A, Pisano JJ. Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus. J Biol Chem. 1985 Feb 10;260(3):1437-44. PubMed PMID: 2578459. 2: Ahmad A, Ranjan S, Zhang W, Zou J, Pyykkö I, Kinnunen PK. Novel endosomolytic peptides for enhancing gene delivery in nanoparticles. Biochim Biophys Acta. 2015 Feb;1848(2):544-53. doi: 10.1016/j.bbamem.2014.11.008. Epub 2014 Nov 15. PubMed PMID: 25445677. 3: Schievano E, Mammi S, Monticelli L, Ciardella M, Peggion E. Conformational studies of a bombolitin III-derived peptide mimicking the four-helix bundle structural motif of proteins. J Am Chem Soc. 2003 Dec 17;125(50):15314-23. PubMed PMID: 14664575. 4: Dohtsu K, Okumura K, Hagiwara K, Palma MS, Nakajima T. Isolation and sequence analysis of peptides from the venom of Protonectarina sylveirae (Hymenoptera-Vespidae). Nat Toxins. 1993;1(5):271-6. PubMed PMID: 7513243.