HS665 HCl CAS#1410935-22-6 | KOP receptor inhibitor

MedKoo Cat#: 563647 | Name: HS665 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HS665 is a novel radioligand designed to bind selectively to the kappa opioid peptide (KOP) receptor, a target of therapeutic interest for the treatment of a variety of human disorders (i.e., pain, affective disorders, drug addiction, and psychotic disorders).

Chemical Structure

HS665 HCl

CAS#1410935-22-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 563647

Name: HS665 HCl

CAS#: 1410935-22-6 (HCl)

Chemical Formula: C21H28ClNO

Exact Mass:

Molecular Weight: 345.91

Elemental Analysis: C, 72.92; H, 8.16; Cl, 10.25; N, 4.05; O, 4.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1409931-92-5 (free base) 1410935-22-6 (HCl)

Synonym

HS665; HS-665; HS 665; HS665 HCl;

IUPAC/Chemical Name

3-[2-(Cyclobutylmethyl-phenethyl-amino)-ethyl]-phenol Hydrochloride

InChi Key

ZRYMGDBUXKLANH-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H27NO.ClH/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18;/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2;1H

SMILES Code

OC1=CC=CC(CCN(CC2CCC2)CCC3=CC=CC=C3)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 345.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu L, Cui Z, Zhu Q, Zha X, Xu Y. Novel Opioid-Receptor Agonists with Reduced Morphine-like Side Effects. Mini Rev Med Chem. 2018 Jul 16. doi: 10.2174/1389557518666180716124336. [Epub ahead of print] PubMed PMID: 30009707. 2: Erli F, Guerrieri E, Ben Haddou T, Lantero A, Mairegger M, Schmidhammer H, Spetea M. Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. J Med Chem. 2017 Sep 14;60(17):7579-7590. doi: 10.1021/acs.jmedchem.7b00981. Epub 2017 Aug 30. PubMed PMID: 28825813; PubMed Central PMCID: PMC5601360. 3: Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. Br J Pharmacol. 2017 Aug;174(15):2444-2456. doi: 10.1111/bph.13854. Epub 2017 Jun 27. PubMed PMID: 28494108; PubMed Central PMCID: PMC5513865. 4: Guerrieri E, Mallareddy JR, Tóth G, Schmidhammer H, Spetea M. Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor. ACS Chem Neurosci. 2015 Mar 18;6(3):456-63. doi: 10.1021/cn5002792. Epub 2014 Dec 24. PubMed PMID: 25496417. 5: Spetea M, Berzetei-Gurske IP, Guerrieri E, Schmidhammer H. Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. J Med Chem. 2012 Nov 26;55(22):10302-6. doi: 10.1021/jm301258w. Epub 2012 Nov 7. PubMed PMID: 23134120.