IFM-2427 | NLRP3 inhibitor

MedKoo Cat#: 124878 | Name: IFM-2427

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IFM-2427 is a NLRP3 inhibitor.

Chemical Structure

IFM-2427

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124878

Name: IFM-2427

CAS#: N/A

Chemical Formula: C19H24N4O3S2

Exact Mass: 420.1300

Molecular Weight: 420.55

Elemental Analysis: C, 54.26; H, 5.75; N, 13.32; O, 11.41; S, 15.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IFM-2427; IFM 2427; IFM2427

IUPAC/Chemical Name

(R)-N'-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-2-(2-hydroxypropan-2-yl)thiazole-5-sulfonimidamide

InChi Key

LHVWNNYPUDZLSH-MUUNZHRXSA-N

InChi Code

InChI=1S/C19H24N4O3S2/c1-19(2,25)17-21-10-15(27-17)28(20,26)23-18(24)22-16-13-7-3-5-11(13)9-12-6-4-8-14(12)16/h9-10,25H,3-8H2,1-2H3,(H3,20,22,23,24,26)/t28-/m1/s1

SMILES Code

O=C(N=[S@@](C1=CN=C(C(C)(O)C)S1)(N)=O)NC2=C3CCCC3=CC4=C2CCC4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

IFM-2427 is a selective small-molecule inhibitor of NLRP3 inflammasome activation, a key regulator of the innate immune response. By targeting the NLRP3 protein, IFM-2427 prevents the formation of the inflammasome complex, thereby reducing the release of pro-inflammatory cytokines such as IL-1β and IL-18. This mechanism makes it a promising therapeutic candidate for inflammatory and autoimmune diseases, including gout, atherosclerosis, and neuroinflammatory disorders.