IFN-alpha | CAS#844882-93-5 | IFN-alpha and IFNAR interaction inhibitor

MedKoo Cat#: 562367 | Name: IFN-alpha

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IFN-alpha, also known as IFNAR-IN-1 or IFN-alpha/IFNAR-IN-1, is a nonpeptidic inhibitor of IFN-alpha and IFNAR interaction.

Chemical Structure

IFN-alpha

CAS#844882-93-5

Theoretical Analysis

MedKoo Cat#: 562367

Name: IFN-alpha

CAS#: 844882-93-5

Chemical Formula: C18H17NS

Exact Mass: 279.1082

Molecular Weight: 279.40

Elemental Analysis: C, 77.38; H, 6.13; N, 5.01; S, 11.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IFN-alpha; IFN alpha; IFNAR-IN-1; IFNAR IN 1; IFNARIN1; IFNAR inhibitor 1; IFNAR-inhibitor-1; IFN-alpha and IFNAR interaction inhibitor;

IUPAC/Chemical Name

Methyl-[2-(naphthalen-1-ylsulfanyl)-benzyl]-amine

InChi Key

OHDXDNUPVVYWOV-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H17NS/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18/h2-12,19H,13H2,1H3

SMILES Code

CNCC1=CC=CC=C1SC2=C3C=CC=CC3=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 279.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aloia AL, Calvert JK, Clarke JN, Davies LT, Helbig KJ, Pitson SM, Carr JM. Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. Clin Transl Immunology. 2017 Jul 21;6(7):e151. doi: 10.1038/cti.2017.32. eCollection 2017 Jul. PubMed PMID: 28791126; PubMed Central PMCID: PMC5539417. 2: Zhao LJ, He SF, Liu Y, Zhao P, Bian ZQ, Qi ZT. Inhibition of STAT Pathway Impairs Anti-Hepatitis C Virus Effect of Interferon Alpha. Cell Physiol Biochem. 2016;40(1-2):77-90. Epub 2016 Nov 18. PubMed PMID: 27855377. 3: Qashqari H, Al-Mars A, Chaudhary A, Abuzenadah A, Damanhouri G, Alqahtani M, Mahmoud M, El Sayed Zaki M, Fatima K, Qadri I. Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance. Infect Genet Evol. 2013 Oct;19:113-9. doi: 10.1016/j.meegid.2013.06.025. Epub 2013 Jul 5. Review. PubMed PMID: 23831932. 4: Tsuno T, Mejido J, Zhao T, Phillips T, Myers TG, Bekisz J, Zoon KC. BID is a critical factor controlling cell viability regulated by IFN-α. J Immunother. 2012 Jan;35(1):23-31. doi: 10.1097/CJI.0b013e3182372dcf. PubMed PMID: 22130162; PubMed Central PMCID: PMC3241910. 5: Vitale G, de Herder WW, van Koetsveld PM, Waaijers M, Schoordijk W, Croze E, Colao A, Lamberts SW, Hofland LJ. IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro. Cancer Res. 2006 Jan 1;66(1):554-62. PubMed PMID: 16397272. 6: Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res. 2005 Nov;25(11):694-701. PubMed PMID: 16318583. 7: Takauji R, Iho S, Takatsuka H, Yamamoto S, Takahashi T, Kitagawa H, Iwasaki H, Iida R, Yokochi T, Matsuki T. CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J Leukoc Biol. 2002 Nov;72(5):1011-9. PubMed PMID: 12429724. 8: Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem. 1996 Apr 5;271(14):8057-61. PubMed PMID: 8626489.