Synonym
Veronicastroside; Lonicerin; Scolymoside;
IUPAC/Chemical Name
7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one
InChi Key
SHPPXMGVUDNKLV-KMFFXDMSSA-N
InChi Code
InChI=1S/C27H30O15/c1-9-20(33)22(35)24(37)26(38-9)42-25-23(36)21(34)18(8-28)41-27(25)39-11-5-14(31)19-15(32)7-16(40-17(19)6-11)10-2-3-12(29)13(30)4-10/h2-7,9,18,20-31,33-37H,8H2,1H3/t9-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
SMILES Code
O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
594.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Inouye H, Aoki Y, Wagner H, Hörhammer L, Aurnhammer G, Budweg W. [The flavone glycosides from Veronicastrum sibiricum Pennell var. japonicum Hara and synthesis of luteolin-7-neohesperidoside (veronicastroside)]. Chem Ber. 1969;102(9):3009-13. German. PubMed PMID: 5806152.
2: Inagaki I, Sakushima A, Hisada S, Nishibe S, Morita N. [Comparison of lonicerin and veronicastroside (author's transl)]. Yakugaku Zasshi. 1974 Apr;94(4):524-5. Japanese. PubMed PMID: 4473018.
3: Lee JH, Han Y. Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Arch Pharm Res. 2011 May;34(5):853-9. doi: 10.1007/s12272-011-0520-6. Epub 2011 Jun 9. PubMed PMID: 21656372.
4: Lin YP, Chen TY, Tseng HW, Lee MH, Chen ST. Neural cell protective compounds isolated from Phoenix hanceana var. formosana. Phytochemistry. 2009 Jun;70(9):1173-81. doi: 10.1016/j.phytochem.2009.06.006. Epub 2009 Jul 21. PubMed PMID: 19628235.
5: Kim NM, Kim J, Chung HY, Choi JS. Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts of Artemisia montana. Arch Pharm Res. 2000 Jun;23(3):237-9. PubMed PMID: 10896054.
6: Hammouda FM, Seif el-Nasr MM, Shahat AA. Flavonoids of Cynara scolymus L. cultivated in Egypt. Plant Foods Hum Nutr. 1993 Sep;44(2):163-9. PubMed PMID: 8378274.
7: Huang X, Li SL, Li P, Li HJ, Chai XY, Song Y. Simultaneous determination of eight main flavonoids in Flos lonicerae by high performance liquid chromatography. Yao Xue Xue Bao. 2005 Mar;40(3):285-8. PubMed PMID: 15952605.
8: Shen CY, Jiang JG, Huang CL, Zhu W, Zheng CY. Polyphenols from Blossoms of Citrus aurantium L. var. amara Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects. J Agric Food Chem. 2017 Oct 18;65(41):9061-9068. doi: 10.1021/acs.jafc.7b03759. Epub 2017 Oct 9. PubMed PMID: 28942652.
