Synonym
(±)-EX-527; (±)-EX 527; (±)-EX527; Selisistat racemate; Selisistat racemic
IUPAC/Chemical Name
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
InChi Key
FUZYTVDVLBBXDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
SMILES Code
O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
248.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Huang J, Tian R, Yang Y, Jiang R, Dai J, Tang L, Zhang L. The SIRT1 inhibitor
EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with
endotoxiemia. Innate Immun. 2017 Nov;23(8):678-686. doi:
10.1177/1753425917733531. Epub 2017 Sep 27. PubMed PMID: 28952835.
2: Tao YF, Lin F, Yan XY, Gao XG, Teng F, Fu ZR, Wang ZX. Galectin-9 in
Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After
Cardiac Transplantation. Transplant Proc. 2015 Jul-Aug;47(6):2003-9. doi:
10.1016/j.transproceed.2015.04.091. PubMed PMID: 26293089.
3: Ohata Y, Matsukawa S, Moriyama Y, Michiue T, Morimoto K, Sato Y, Kuroda H.
Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations,
and gastrointestinal malformations in Xenopus laevis embryos. Dev Growth Differ.
2014 Aug;56(6):460-8. doi: 10.1111/dgd.12145. Epub 2014 Aug 5. PubMed PMID:
25131500.
4: Gertz M, Fischer F, Nguyen GT, Lakshminarasimhan M, Schutkowski M, Weyand M,
Steegborn C. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent
deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81.
doi: 10.1073/pnas.1303628110. Epub 2013 Jul 9. PubMed PMID: 23840057; PubMed
Central PMCID: PMC3725051.
