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MedKoo Cat#: 592784 | Name: Diloxanide furoate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diloxanide furoate is an ambecide, an anti-protozoal drug used in the treatment of amoebozoa infections

Chemical Structure

Diloxanide furoate
CAS#3736-81-0

Theoretical Analysis

MedKoo Cat#: 592784

Name: Diloxanide furoate

CAS#: 3736-81-0

Chemical Formula: C14H11Cl2NO4

Exact Mass: 327.0065

Molecular Weight: 328.15

Elemental Analysis: C, 51.24; H, 3.38; Cl, 21.61; N, 4.27; O, 19.50

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Diloxanide furoate; Amebiazol; Histomibal; Miforon; Dichlofurazol; Furentomin; NSC-759146; NSC759146; NSC759146;
IUPAC/Chemical Name
4-(2,2-dichloro-N-methylacetamido)phenyl furan-2-carboxylate
InChi Key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
SMILES Code
O=C(N(C)C1=CC=C(OC(C2=CC=CO2)=O)C=C1)C(Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
Ethanol 20.0 60.95
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 328.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Issa MM, Nejem RM, Abu Shanab AM, Shaat NT. Kinetic spectrophotometric H-point standard addition method for the simultaneous determination of diloxanide furoate and metronidazole in binary mixtures and biological fluids. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct;114:592-8. doi: 10.1016/j.saa.2013.05.062. Epub 2013 Jun 5. PubMed PMID: 23807049. 2: Abbas SS, Wagieh NE, Abdelkawy M, Abdelrahman MM. Simultaneous determination of diloxanide furoate and metronidazole in presence of diloxanide furoate degradation products. J AOAC Int. 2011 Sep-Oct;94(5):1427-39. PubMed PMID: 22165007. 3: Mabrouk M, El-Fatatry H, Hewala I, Emam E. Development and application of a novel, dual-mode gradient, stability-indicating HPLC-DAD method for the simultaneous determination and purity assessment of mebeverine hydrochloride, diloxanide furoate and their corresponding major degradation products in combination with some gastrointestinal drugs in the form of oral doses. J Pharm Biomed Anal. 2013 Sep;83:249-59. doi: 10.1016/j.jpba.2013.04.013. Epub 2013 Apr 19. PubMed PMID: 23770637. 4: Tiwari V, Verma S, Verma SK, Dangi JS. Enhancement of site specific delivery of diloxanide furoate as an antiamoebic drug. Eur J Pharm Sci. 2016 Apr 30;86:50-7. doi: 10.1016/j.ejps.2016.03.001. Epub 2016 Mar 4. PubMed PMID: 26952868. 5: Al-Ghanam SM, Belal F. Spectrophotometric determination of diloxanide furoate in its dosage forms. Farmaco. 2001 Sep;56(9):677-81. PubMed PMID: 11680811. 6: Qureshi H, Ali A, Baqai R, Ahmed W. Efficacy of a combined diloxanide furoate-metronidazole preparation in the treatment of amoebiasis and giardiasis. J Int Med Res. 1997 May-Jun;25(3):167-70. PubMed PMID: 9178149. 7: Thorén K, Håkansson C, Bergström T, Johanisson G, Norkrans G. Treatment of asymptomatic amebiasis in homosexual men. Clinical trials with metronidazole, tinidazole, and diloxanide furoate. Sex Transm Dis. 1990 Apr-Jun;17(2):72-4. PubMed PMID: 2193407. 8: Pehrson P, Bengtsson E. Treatment of non-invasive amoebiasis. A comparison between tinidazole alone and in combination with diloxanide furoate. Trans R Soc Trop Med Hyg. 1983;77(6):845-6. PubMed PMID: 6665837. 9: McAuley JB, Herwaldt BL, Stokes SL, Becher JA, Roberts JM, Michelson MK, Juranek DD. Diloxanide furoate for treating asymptomatic Entamoeba histolytica cyst passers: 14 years' experience in the United States. Clin Infect Dis. 1992 Sep;15(3):464-8. PubMed PMID: 1520794. 10: Anande NM, Jain SK, Jain NK. Con-A conjugated mucoadhesive microspheres for the colonic delivery of diloxanide furoate. Int J Pharm. 2008 Jul 9;359(1-2):182-9. doi: 10.1016/j.ijpharm.2008.04.009. Epub 2008 Apr 12. PubMed PMID: 18486369. 11: Bhopale KK, Pradhan KS, Masani KB, Kaul CL. Additive effect of diloxanide furoate and metronidazole (Entamizole) in experimental mouse caecal amoebiasis. Indian J Exp Biol. 1995 Jan;33(1):73-4. PubMed PMID: 9135682. 12: Sengupta M, Dutta H, Pal DK, De AU, Sengupta C. Correlation of phospholipid loss in goat whole blood with solvochromic properties of antiamebics like emetine, metronidazole and diloxanide furoate. Indian J Exp Biol. 1993 Jan;31(1):21-5. PubMed PMID: 8500812. 13: Osisanya JO. Comparative in vitro activity of mefloquine, diloxanide furoate and other conventionally used amoebicides against entamoeba histolytica. East Afr Med J. 1986 Apr;63(4):263-8. PubMed PMID: 2874011. 14: Mishal A, Sober D. Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form. J Pharm Biomed Anal. 2005 Sep 15;39(3-4):819-23. PubMed PMID: 16055294. 15: Monteiro JB, Chiaradia LD, Brandão TA, Magro JD, Yunes RA. Enzymatic hydrolysis of diloxanide furoate in the presence of beta-cyclodextrin and its methylated derivatives. Int J Pharm. 2003 Nov 28;267(1-2):93-100. PubMed PMID: 14602387. 16: Rubidge CJ, Scragg JN, Powell SJ. Treatment of children with acute amoebic dysentery. Comparative trial of metronidazole against a combination of dehydroemetine, tetracycline, and diloxanide furoate. Arch Dis Child. 1970 Apr;45(240):196-7. PubMed PMID: 4315969; PubMed Central PMCID: PMC2020286. 17: Hasan NY, Elkawy MA, Elzeany BE, Wagieh NE. Stability indicating methods for the determination of diloxanide furoate. J Pharm Biomed Anal. 2002 Apr 15;28(2):187-97. PubMed PMID: 11929661. 18: Pai PN, Rao GK, Srinivas B, Puranik S. RPLC Determination of Tinidazole and Diloxanide Furoate in Tablets. Indian J Pharm Sci. 2008 Sep;70(5):670-2. doi: 10.4103/0250-474X.45415. PubMed PMID: 21394273; PubMed Central PMCID: PMC3038301. 19: Gadkariem EA, Belal F, Abounassif MA, El-Obeid HA, E E Ibrahim K. Stability studies on diloxanide furoate: effect of pH, temperature, gastric and intestinal fluids. Farmaco. 2004 Apr;59(4):323-9. PubMed PMID: 15081350. 20: Castro Hermida JA, Ares-Mazás ME, Nieto Reyes L, Otero Espinar F, Blanco Méndez J. Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate. Parasitol Res. 2001 Jun;87(6):449-52. PubMed PMID: 11411943.