Synonym
Clogestone (free base), Clogestonum, Clogestona
IUPAC/Chemical Name
Pregna-4,6-dien-20-one, 6-chloro-3,17-dihydroxy-, (3beta)-
InChi Key
WZTUZRFSDWXDRM-IAGOJMRCSA-N
InChi Code
InChI=1S/C21H29ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,13-16,24-25H,4-9H2,1-3H3/t13-,14+,15-,16-,19+,20-,21-/m0/s1
SMILES Code
CC([C@@]1(O)CC[C@@]2([H])[C@]3([H])C=C(Cl)C4=C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.91
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Elder MG, Myatt L, Chaudhuri G. The effect of norgestrel and clogestone on the spontaneous motility of the human fallopian tube. Int J Fertil. 1978;23(1):61-4. PMID: 30711.
2: Hinselmann M, Jürgensen O, Hasselblatt I, Otten U, Prinz W, Taubert HD. Klinische Untersuchungen mit dem neuartigen Gestagen Clogestonacetat [Clogestone acetate, a new orally effective progestagen]. Arch Gynakol. 1970 Aug 31;209(2):136-48. German. doi: 10.1007/BF00668180. PMID: 5537778.
3: Zacharias S, Aguilera E, Assenzo JR, Zanartu J. Effects of hormonal and nonhormonal contraceptives on lactation and incidence of pregnancy. Contraception. 1986 Mar;33(3):203-13. doi: 10.1016/0010-7824(86)90014-4. PMID: 2941236.
4: Stern MD, Givner ML. Measurement of serum clogestone acetate (AY-11,440) by a radioreceptor assay: a practical approach to the quantitative determination of synthetic progestins. J Clin Endocrinol Metab. 1975 Apr;40(4):728-31. doi: 10.1210/jcem-40-4-728. PMID: 1127082.
5: Di Carlo F, Conti G, Reboani C. Interference of gestagens and androgens with rat uterine oestrogen receptors. J Endocrinol. 1978 Apr;77(1):49-55. doi: 10.1677/joe.0.0770049. PMID: 147913.
6: Di Carlo F, Pacilio G, Conti G. Sul meccanismo d'azione dei progestinici nella terapia dei tumori mammari ormono - dipendenti [Mechanism of action of progestins in the treatment of hormone-dependent breast cancer (author's transl)]. Tumori. 1975 Nov-Dec;61(6):501-8. Italian. PMID: 1224393.
7: Vázquez E, Arias J, Alvarez M. Progestational activity of a new diacetate progesterone derivative. J Reprod Med. 1970 Aug;5(2):84-9. PMID: 5521774.
