Synonym
Racemethionine; NSC 9241; NSC-9241; NSC9241; Dyprin; DL-methionine; Neston;
IUPAC/Chemical Name
methionine
InChi Key
FFEARJCKVFRZRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
SMILES Code
O=C(O)C(N)CCSC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in water
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in water
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Racemethionine is an essential amino acid containing sulfur with oxidative stress defense effects. Racemethionine can be used for animal natural feed. It also kills H. rostochiensis on potato plants.
In vitro activity:
This study revealed that Racemethionine had a better absorption and metabolization than DL-Methionine Hydroxy Analog in fish cell lines. These results suggest that both synthetic methionine sources are not biologically equivalent, suggesting similar in vivo effects in rainbow trout liver and, therefore, questioning the DL-Methionine Hydroxy Analog efficiencies in other rainbow trout tissues.
Reference: Int J Mol Sci. 2022 Mar 8;23(6):2935. https://pubmed.ncbi.nlm.nih.gov/35328356/
In vivo activity:
Sixty consecutive patients of either sex, above the age of 18 years with symptoms of osteo-arthritis participated in this open, randomised, comparative clinical trial carried out over 3 months. The combination treatment of nimesulide and racemethionine was found to be better for the long-term treatment of osteo-arthritis in patients.
Reference: J Indian Med Assoc. 2008 Jun;106(6):402-4. https://pubmed.ncbi.nlm.nih.gov/18839654/
|
Solvent |
mg/mL |
mM |
| Solubility |
| Water |
33.3 |
223.38 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
149.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Pinel K, Heraud C, Morin G, Dias K, Marcé A, Beauclair L, Fontagné-Dicharry S, Masagounder K, Klünemann M, Seiliez I, Beaumatin F. Are the Main Methionine Sources Equivalent? A Focus on DL-Methionine and DL-Methionine Hydroxy Analog Reveals Differences on Rainbow Trout Hepatic Cell Lines Functions. Int J Mol Sci. 2022 Mar 8;23(6):2935. doi: 10.3390/ijms23062935. PMID: 35328356; PMCID: PMC8954868.
2. Patterson JA, Kung L Jr. Metabolism of DL-methionine and methionine analogs by rumen microorganisms. J Dairy Sci. 1988 Dec;71(12):3292-301. doi: 10.3168/jds.S0022-0302(88)79934-8. PMID: 3235731.
3. Prabhu VV. A comparative clinical trial evaluating efficacy and safety of fixed dose combination of nimesulide (100 mg) and racemethionine (50 mg) (namsafe) versus reference drug (nimesulide) and other NSAIDs in the treatment of osteoarthritis. J Indian Med Assoc. 2008 Jun;106(6):402-4. PMID: 18839654.
4. Tang X, Yang Y, Shi Y, Le G. Comparative in vivo antioxidant capacity of DL-2-hydroxy-4-methylthiobutanoic acid (HMTBA) and DL-methionine in male mice fed a high-fat diet. J Sci Food Agric. 2011 Sep;91(12):2166-72. doi: 10.1002/jsfa.4434. Epub 2011 May 12. PMID: 21567412.
In vitro protocol:
1. Pinel K, Heraud C, Morin G, Dias K, Marcé A, Beauclair L, Fontagné-Dicharry S, Masagounder K, Klünemann M, Seiliez I, Beaumatin F. Are the Main Methionine Sources Equivalent? A Focus on DL-Methionine and DL-Methionine Hydroxy Analog Reveals Differences on Rainbow Trout Hepatic Cell Lines Functions. Int J Mol Sci. 2022 Mar 8;23(6):2935. doi: 10.3390/ijms23062935. PMID: 35328356; PMCID: PMC8954868.
2. Patterson JA, Kung L Jr. Metabolism of DL-methionine and methionine analogs by rumen microorganisms. J Dairy Sci. 1988 Dec;71(12):3292-301. doi: 10.3168/jds.S0022-0302(88)79934-8. PMID: 3235731.
In vivo protocol:
1. Prabhu VV. A comparative clinical trial evaluating efficacy and safety of fixed dose combination of nimesulide (100 mg) and racemethionine (50 mg) (namsafe) versus reference drug (nimesulide) and other NSAIDs in the treatment of osteoarthritis. J Indian Med Assoc. 2008 Jun;106(6):402-4. PMID: 18839654.
2. Tang X, Yang Y, Shi Y, Le G. Comparative in vivo antioxidant capacity of DL-2-hydroxy-4-methylthiobutanoic acid (HMTBA) and DL-methionine in male mice fed a high-fat diet. J Sci Food Agric. 2011 Sep;91(12):2166-72. doi: 10.1002/jsfa.4434. Epub 2011 May 12. PMID: 21567412.
1: Prabhu VV. A comparative clinical trial evaluating efficacy and safety of fixed dose combination of nimesulide (100 mg) and racemethionine (50 mg) (namsafe) versus reference drug (nimesulide) and other NSAIDs in the treatment of osteoarthritis. J Indian Med Assoc. 2008 Jun;106(6):402-4. PubMed PMID: 18839654.
2: Jankowski J, Ognik K, Kubinska M, Czech A, Juskiewicz J, Zdunczyk Z. The effect of DL-, L-isomers and DL-hydroxy analog administered at 2 levels as dietary sources of methionine on the metabolic and antioxidant parameters and growth performance of turkeys. Poult Sci. 2017 Sep 1;96(9):3229-3238. doi: 10.3382/ps/pex099. PubMed PMID: 28521012.
3: Albrecht A, Herbert U, Miskel D, Heinemann C, Braun C, Dohlen S, Zeitz JO, Eder K, Saremi B, Kreyenschmidt J. Effect of methionine supplementation in chicken feed on the quality and shelf life of fresh poultry meat. Poult Sci. 2017 Aug 1;96(8):2853-2861. doi: 10.3382/ps/pex071. PubMed PMID: 28419366.
4: Park I, Pasquetti T, Malheiros RD, Ferket PR, Kim SW. Effects of supplemental L-methionine on growth performance and redox status of turkey poults compared with the use of DL-methionine. Poult Sci. 2018 Jan 1;97(1):102-109. doi: 10.3382/ps/pex259. PubMed PMID: 29077910; PubMed Central PMCID: PMC5850274.
