Synonym
AtuFECT01; Atu FECT01; Atu-FECT01;
IUPAC/Chemical Name
(S)-5-((amino(iminio)methyl)amino)-1-(((S)-2-ammonio-3-(((Z)-octadec-9-en-1-yl)(octadecyl)amino)-3-oxopropyl)amino)-1-oxopentan-2-aminium chloride
InChi Key
BODCXNSAWWEBPF-PTUOKWFHSA-N
InChi Code
InChI=1S/C45H91N7O2.3ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38-52(44(54)42(47)40-51-43(53)41(46)36-35-37-50-45(48)49)39-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;;;/h17,19,41-42H,3-16,18,20-40,46-47H2,1-2H3,(H,51,53)(H4,48,49,50);3*1H/b19-17-;;;/t41-,42-;;;/m0.../s1
SMILES Code
NC(NCCC[C@H]([NH3+])C(NC[C@H]([NH3+])C(N(CCCCCCCCCCCCCCCCCC)CCCCCCCC/C=C\CCCCCCCC)=O)=O)=[NH2+].[Cl-].[Cl-].[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
871.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Charbe NB, Amnerkar ND, Ramesh B, Tambuwala MM, Bakshi HA, Aljabali AAA, Khadse SC, Satheeshkumar R, Satija S, Metha M, Chellappan DK, Shrivastava G, Gupta G, Negi P, Dua K, Zacconi FC. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13. PMID: 33304780; PMCID: PMC7714980.
2: Williamson B, Soars AC, Owen A, White P, Riley RJ, Soars MG. Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA. Xenobiotica. 2013 Oct;43(10):920-31. doi: 10.3109/00498254.2013.776194. Epub 2013 Mar 6. PMID: 23461378.
