Synonym
Prostalene; RS-9390; RS 9390; RS9390; Synchrocept;
IUPAC/Chemical Name
methyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hepta-4,5-dienoate
InChi Key
GNIYHUSSKSFYBD-DPUKWMSOSA-N
InChi Code
InChI=1S/C22H36O5/c1-4-5-10-14-22(2,26)15-13-18-17(19(23)16-20(18)24)11-8-6-7-9-12-21(25)27-3/h7-8,13,15,17-20,23-24,26H,4-5,9-12,14,16H2,1-3H3/b15-13+/t6?,17-,18-,19+,20-,22?/m1/s1
SMILES Code
CCCCCC(C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)CC=C=CCCC(OC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
380.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bosu WT, McKinnon AO. Induction of abortion during midgestation in mares. Can Vet J. 1982 Dec;23(12):358-60. PubMed PMID: 17422207; PubMed Central PMCID: PMC1790269.
2: Ley WB, Purswell BJ, Bowen JM. The effects of prostalene and alfaprostol as uterine myotonics, and the effect on postpartum pregnancy rate in the mare following daily treatment with prostalene. Theriogenology. 1988;29(5):1113-21. PubMed PMID: 16726434.
3: Vickery BH, McRae GI, Bajka A. Luteolysis and termination of early pregnancy in the rhesus monkey with prostalene, a synthetic prostaglandin analog. Prostaglandins Med. 1979 Mar;2(3):191-201. PubMed PMID: 121604.
4: Averkin G, Schiltz R. Summary of the effect of prostalene, a new synthetic prostaglandin, on the breeding efficiency of mares. Vet Med Small Anim Clin. 1976 Nov;71(11):1616, 1621-3. PubMed PMID: 1049488.
5: Hamm D, Witherspoon DM, Buell JR, Chen CL, Jöchle W. Determination of clinical and luteolytic effectiveness of a prostaglandin analog in mares by a dose response study. Theriogenology. 1981 Oct;16(4):447-57. PubMed PMID: 16725656.
6: Vickery B, Briones W, Holstein A. Opposite and mutually antagonistic effects on uterine contractility of two epimeric forms of a synthetic prostaglandin analog. Prostaglandins Med. 1979 Jan;2(1):3-10. PubMed PMID: 550139.
7: Loy RG, Buell JR, Stevenson W, Hamm D. Sources of variation in response intervals after prostaglandin treatment in mares with functional corpora lutea. J Reprod Fertil Suppl. 1979;(27):229-35. PubMed PMID: 289794.
8: Imel KJ, Squires EL, Elsden RP, Shideler RK. Collection and transfer of equine embryos. J Am Vet Med Assoc. 1981 Nov 15;179(10):987-91. PubMed PMID: 7341563.
