PROTAC NR-7h | CAS#unknown | Degrader

MedKoo Cat#: 208252 | Name: PROTAC NR-7h

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PROTAC NR-7h could play an important role in MAYV replication and could serve as a therapeutic target to control MAYV infection. Knockdown of p38⍺/p38β isoforms was performed in HDFs using the PROTACs molecule NR-7h

Chemical Structure

PROTAC NR-7h

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208252

Name: PROTAC NR-7h

CAS#: unknown

Chemical Formula: C48H50BrF2N9O8

Exact Mass: 997.2934

Molecular Weight: 998.88

Elemental Analysis: C, 57.72; H, 5.05; Br, 8.00; F, 3.80; N, 12.62; O, 12.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PROTAC NR7h, PROTAC-NR-7h, PROTACNR7h

IUPAC/Chemical Name

3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide

InChi Key

GVMNPTPONPPKFH-UHFFFAOYSA-N

InChi Code

InChI=1S/C48H50BrF2N9O8/c1-28-10-11-30(24-38(28)59-29(2)23-39(44(49)48(59)67)68-27-31-13-14-32(50)25-35(31)51)12-16-41(62)54-21-18-33-26-58(57-56-33)22-6-9-40(61)53-20-4-3-19-52-36-8-5-7-34-43(36)47(66)60(46(34)65)37-15-17-42(63)55-45(37)64/h5,7-8,10-11,13-14,23-26,37,52H,3-4,6,9,12,15-22,27H2,1-2H3,(H,53,61)(H,54,62)(H,55,63,64)

SMILES Code

CC(C(N1C(C(Br)=C(OCC2=C(F)C=C(F)C=C2)C=C1C)=O)=C3)=CC=C3CCC(NCCC(N=N4)=CN4CCCC(NCCCCNC5=C(C(C6=O)=CC=C5)C(N6C7CCC(NC7=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 998.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Sugasti-Salazar M, Llamas-González YY, Campos D, González-Santamaría J. Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells. Viruses. 2021 Jun 17;13(6):1156. doi: 10.3390/v13061156. PMID: 34204188; PMCID: PMC8233896.