RS 42358-197 | CAS#135729-55-4 | 5-HT3 receptor antagonist

MedKoo Cat#: 461491 | Name: RS 42358-197

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS 42358-197 is the S-isomer of the novel 5-HT3 receptor antagonist RS-42358.

Chemical Structure

RS 42358-197

CAS#135729-55-4

Theoretical Analysis

MedKoo Cat#: 461491

Name: RS 42358-197

CAS#: 135729-55-4

Chemical Formula: C19H23ClN2O

Exact Mass: 330.1499

Molecular Weight: 330.85

Elemental Analysis: C, 68.98; H, 7.01; Cl, 10.71; N, 8.47; O, 4.84

Price and Availability

Size	Price	Availability	Quantity
15mg	USD 1,500.00

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Related CAS #

No Data

Synonym

RS 42358-197; RS42358-197; RS-42358-197;

IUPAC/Chemical Name

(S)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride

InChi Key

PEMWWRCTBNOHCX-UNTBIKODSA-N

InChi Code

InChI=1S/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m1./s1

SMILES Code

O=C1N([C@@H]2CN3CCC2CC3)C=C4C5=C1C=CC=C5CCC4.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bonhaus DW, Stefanich E, Loury DN, Hsu SA, Eglen RM, Wong EH. Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors. J Neurochem. 1995 Jul;65(1):104-10. doi: 10.1046/j.1471-4159.1995.65010104.x. PMID: 7790853. 2: Wong EH, Clark R, Leung E, Loury D, Bonhaus DW, Jakeman L, Parnes H, Whiting RL, Eglen RM. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br J Pharmacol. 1995 Feb;114(4):851-9. doi: 10.1111/j.1476-5381.1995.tb13282.x. PMID: 7773546; PMCID: PMC1510197. 3: Wong EH, Bonhaus DW, Eglen RM. The identification of heterogeneity of 5-HT3 receptors with [3H]RS-42358-197. Adv Exp Med Biol. 1995;363:97-108. doi: 10.1007/978-1-4615-1857-0_12. PMID: 7618534. 4: Eglen RM, Bonhaus DW, Clark RD, Johnson LG, Lee CH, Leung E, Smith WL, Wong EH, Whiting RL. (R) and (S) RS 56532: mixed 5-HT3 and 5-HT4 receptor ligands with opposing enantiomeric selectivity. Neuropharmacology. 1994 Mar- Apr;33(3-4):515-26. doi: 10.1016/0028-3908(94)90083-3. PMID: 7984291. 5: Bonhaus DW, Wong EH, Stefanich E, Kunysz EA, Eglen RM. Pharmacological characterization of 5-hydroxytryptamine3 receptors in murine brain and ileum using the novel radioligand [3H]RS-42358-197: evidence for receptor heterogeneity. J Neurochem. 1993 Nov;61(5):1927-32. doi: 10.1111/j.1471-4159.1993.tb09835.x. PMID: 8229003. 6: Eglen RM, Bley K, Bonhaus DW, Clark RD, Hegde SS, Johnson LG, Leung E, Wong EH. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26. doi: 10.1111/j.1476-5381.1993.tb13780.x. PMID: 8220871; PMCID: PMC2176024. 7: Eglen RM, Lee CH, Smith WL, Johnson LG, Whiting RL, Hegde SS. RS 42358-197, a novel and potent 5-HT3 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1993 Aug;266(2):535-43. PMID: 8355189. 8: Costall B, Domeney AM, Kelly ME, Tomkins DM, Naylor RJ, Wong EH, Smith WL, Whiting RL, Eglen RM. The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol. 1993 Mar 30;234(1):91-9. doi: 10.1016/0014-2999(93)90710-y. PMID: 8097165. 9: Wong EH, Bonhaus DW, Wu I, Stefanich E, Eglen RM. Labelling of 5-hydroxytryptamine3 receptors with a novel 5-HT3 receptor ligand, [3H]RS-42358-197. J Neurochem. 1993 Mar;60(3):921-30. doi: 10.1111/j.1471-4159.1993.tb03238.x. PMID: 8436978.