LY 353433 | CAS#176390-32-2

MedKoo Cat#: 529187 | Name: LY 353433

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 353433 is a 5-HT(4) receptor antagonist.

Chemical Structure

LY 353433

CAS#176390-32-2

Theoretical Analysis

MedKoo Cat#: 529187

Name: LY 353433

CAS#: 176390-32-2

Chemical Formula: C29H41N5O2

Exact Mass: 491.3260

Molecular Weight: 491.68

Elemental Analysis: C, 70.84; H, 8.41; N, 14.24; O, 6.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LY 353433

IUPAC/Chemical Name

1H-Indazole-3-carboxamide, 1-(1-methylethyl)-N-(2-(4-((tricyclo(3.3.1.13,7)dec-1-ylcarbonyl)amino)-1-piperidinyl)ethyl)-

InChi Key

QEZYDSSGVBTNBH-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H41N5O2/c1-19(2)34-25-6-4-3-5-24(25)26(32-34)27(35)30-9-12-33-10-7-23(8-11-33)31-28(36)29-16-20-13-21(17-29)15-22(14-20)18-29/h3-6,19-23H,7-18H2,1-2H3,(H,30,35)(H,31,36)

SMILES Code

O=C(C1=NN(C(C)C)C2=C1C=CC=C2)NCCN3CCC(NC(C4(C5)CC6CC5CC(C6)C4)=O)CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 491.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schaus JM, Thompson DC, Bloomquist WE, Susemichel AD, Calligaro DO, Cohen ML. Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives. J Med Chem. 1998 May 21;41(11):1943-55. PubMed PMID: 9599243. 2: Cohen ML, Bloomquist W, Schaus JM, Thompson DC, Susemichel AD, Calligaro DA, Cohen I. LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190. J Pharmacol Exp Ther. 1996 Apr;277(1):97-104. PubMed PMID: 8613972.