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MedKoo Cat#: 598840 | Name: Lidamidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lidamidine is an intermediate in the synthesis of Lidamidine Hydrochloride which is a novel antidiarrheal agent that has potent antimotility, antidiarrheal and antisecretory activity. It also significantly reduces the total number of bowel movements and the loss of liquids in healthy people with senna-induced diarrhea.

Chemical Structure

Lidamidine
Lidamidine
CAS#66871-56-5 (free base)

Theoretical Analysis

MedKoo Cat#: 598840

Name: Lidamidine

CAS#: 66871-56-5 (free base)

Chemical Formula: C11H16N4O

Exact Mass: 220.1324

Molecular Weight: 220.27

Elemental Analysis: C, 59.98; H, 7.32; N, 25.44; O, 7.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
65009-35-0(HCl) 66871-56-5 (free base)
Synonym
Lidamidine; Lidamidina; Lidamidinum;
IUPAC/Chemical Name
N-(2,6-Dimethylphenyl)-N'-(imino(methylamino)methyl)urea
InChi Key
RRHJHSBDJDZUGL-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16N4O/c1-7-5-4-6-8(2)9(7)14-11(16)15-10(12)13-3/h4-6H,1-3H3,(H4,12,13,14,15,16)
SMILES Code
O=C(NC(NC)=N)NC1=C(C)C=CC=C1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 220.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Eaker EY, Bixler GB, Mathias JR. WHR 1049, a potent metabolite of lidamidine, has antidiarrheal and antimotility effects on the small intestine in rats. J Pharmacol Exp Ther. 1988 Aug;246(2):786-9. PubMed PMID: 3404458. 2: Wienbeck M, Bohn M. Different actions of 2 antidiarrheal agents, lidamidine and loperamide, on motility of the isolated cat colon muscle. Z Gastroenterol. 1985 Apr;23(4):175-82. PubMed PMID: 4060808. 3: Awad RA, Llorens F, Camelo AL, Sánchez M. A randomised double-blind placebo-controlled trial of lidamidine HCL in irritable bowel syndrome. Acta Gastroenterol Latinoam. 2000;30(3):169-75. PubMed PMID: 10975022. 4: Bleakman D, Naftalin RJ. Prevention of guanine nucleotide-induced reductions in muscarinic agonist binding to rabbit ileal submucosal membranes by lidamidine and tetracaine. Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):366-72. PubMed PMID: 2900471. 5: Sninsky CA, Davis RH, Clench MH, Thomas KD, Mathias JR. Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A double-blind study. Gastroenterology. 1986 Jan;90(1):68-73. PubMed PMID: 3940258. 6: Durbin T, Rosenthal L, McArthur K, Anderson D, Dharmsathaphorn K. Clonidine and lidamidine (WHR-1142) stimulate sodium and chloride absorption in the rabbit intestine. Gastroenterology. 1982 Jun;82(6):1352-8. PubMed PMID: 6121738. 7: Rodríguez Magallán A, Valadéz Velázquez T, Llorens Torres F, Sánchez Torres MI. [Treatment of irritable colon with lidamidine and support psychotherapy]. Rev Gastroenterol Mex. 1997 Jan-Mar;62(1):7-13. Spanish. PubMed PMID: 9190662. 8: Decktor DL, Pendleton RG, Ensslen ME, Davis MM. Lidamidine inhibits intrinsic contractile patterns of the rat proximal colon. Eur J Pharmacol. 1987 Nov 10;143(2):213-9. PubMed PMID: 2891549. 9: McArthur KE, Anderson DS, Durbin TE, Orloff MJ, Dharmsathaphorn K. Clonidine and lidamidine to inhibit watery diarrhea in a patient with lung cancer. Ann Intern Med. 1982 Mar;96(3):323-5. PubMed PMID: 7059095. 10: Krebs JB, Mir GN. Spasmolytic effect of lidamidine on uterine smooth muscle. Arzneimittelforschung. 1981;31(8):1251-4. PubMed PMID: 6945863. 11: Allison MC, Sercombe J, Pounder RE. A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea. Aliment Pharmacol Ther. 1988 Aug;2(4):347-51. PubMed PMID: 2979258. 12: Gasbarrini G, Corazza GR, Feliciani M, Albano O, Stufano N, Altomare E, Fontana G, Valpiani D, Chiodo F, Banterle C, et al. A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea. Arzneimittelforschung. 1986 Dec;36(12):1843-5. PubMed PMID: 3551969. 13: Masukawa H, Kaneko M, Takahashi T, Ishikawa M, Suzuki Y. Effect of lidamidine on transepithelial potential difference evoked by prostaglandin E2 in human jejunum. Gastroenterol Jpn. 1987 Oct;22(5):588-90. PubMed PMID: 2445615. 14: DiJoseph JF, Mir GN. Hyperglycemic effect of lidamidine in the rat. Arch Int Pharmacodyn Ther. 1987 Aug;288(2):300-8. PubMed PMID: 2890331. 15: Procaccini RL, Klunk LJ. The subcellular distribution of 14C-lidamidine and its metabolites. Drug Metab Dispos. 1981 May-Jun;9(3):202-6. PubMed PMID: 6113926.