LASSBio-1135 | CAS#852453-71-5 | TRPV1 antagonist

MedKoo Cat#: 563526 | Name: LASSBio-1135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LASSBio-1135 is a dual TRPV1 antagonist and TNF-alpha production inhibitor.

Chemical Structure

LASSBio-1135

CAS#852453-71-5

Theoretical Analysis

MedKoo Cat#: 563526

Name: LASSBio-1135

CAS#: 852453-71-5

Chemical Formula: C18H14N4

Exact Mass: 286.1218

Molecular Weight: 286.33

Elemental Analysis: C, 75.50; H, 4.93; N, 19.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LASSBio-1135; LASSBio 1135; LASSBio1135

IUPAC/Chemical Name

Phenyl-(2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine

InChi Key

ULQALHCOPZRDMC-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14N4/c1-2-8-14(9-3-1)20-18-17(15-10-4-6-12-19-15)21-16-11-5-7-13-22(16)18/h1-13,20H

SMILES Code

C12=NC(C3=NC=CC=C3)=C(NC4=CC=CC=C4)N1C=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lima CK, Silva RM, Lacerda RB, Santos BL, Silva RV, Amaral LS, Quintas LE, Fraga CA, Barreiro EJ, Guimaraes MZ, Miranda AL. LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. PLoS One. 2014 Jun 18;9(6):e99510. doi: 10.1371/journal.pone.0099510. eCollection 2014. PubMed PMID: 24941071; PubMed Central PMCID: PMC4062389. 2: Lacerda RB, de Lima CK, da Silva LL, Romeiro NC, Miranda AL, Barreiro EJ, Fraga CA. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes. Bioorg Med Chem. 2009 Jan 1;17(1):74-84. doi: 10.1016/j.bmc.2008.11.018. Epub 2008 Nov 17. PubMed PMID: 19059783.