Synonym
RS 1893; RS-1893; RS1893;
IUPAC/Chemical Name
2-(2-chloro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy)-N-(2-morpholinoethyl)acetamide
InChi Key
BJDABAAESZGWTK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23ClN4O4/c19-14-11-13(15-2-4-17(24)22-21-15)1-3-16(14)27-12-18(25)20-5-6-23-7-9-26-10-8-23/h1,3,11H,2,4-10,12H2,(H,20,25)(H,22,24)
SMILES Code
O=C(NCCN1CCOCC1)COC2=CC=C(C(CC3)=NNC3=O)C=C2Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Miyake S, Shiga H, Koike H, Mizuno H, Yorikane R, Oda T, Iijima Y, Kumakura S, Morisawa Y. Cardiovascular pharmacology of RS-1893, an orally active cardiotonic agent with arterial and venous vasodilator actions. Jpn J Pharmacol. 1988 Jul;47(3):273-83. PubMed PMID: 2851676.
2: Miyake S, Shiga H, Koike H. Arterial and venous vasodilator actions of RS-1893, a novel cardiotonic agent, in the hindlimb preparation of the dog. J Cardiovasc Pharmacol. 1989 Oct;14(4):526-33. PubMed PMID: 2478765.
3: Miyake S, Shiga H, Sada T, Oizumi K, Koike H. Effects of RS-1893, a novel cardiotonic agent, on central and peripheral hemodynamics in anesthetized rats. Jpn J Pharmacol. 1989 Dec;51(4):577-80. PubMed PMID: 2615052.
