MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 598778 | Name: LG 6-101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG 6-101 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.

Chemical Structure

LG 6-101
LG 6-101
CAS#132798-26-6

Theoretical Analysis

MedKoo Cat#: 598778

Name: LG 6-101

CAS#: 132798-26-6

Chemical Formula: C22H32ClNO3S

Exact Mass:

Molecular Weight: 426.01

Elemental Analysis: C, 62.03; H, 7.57; Cl, 8.32; N, 3.29; O, 11.27; S, 7.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
LG 6-101; LG-6-101; LG6-101;
IUPAC/Chemical Name
1-(3-(3-(isobutylamino)-2-methoxypropoxy)-4-methylthiophen-2-yl)-3-phenylpropan-1-one hydrochloride
InChi Key
DTIZUFNQHYOWFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H31NO3S.ClH/c1-16(2)12-23-13-19(25-4)14-26-21-17(3)15-27-22(21)20(24)11-10-18-8-6-5-7-9-18;/h5-9,15-16,19,23H,10-14H2,1-4H3;1H
SMILES Code
O=C(C1=C(OCC(OC)CNCC(C)C)C(C)=CS1)CCC2=CC=CC=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LG 6-101 is a new propafenone-related antiarrhythmic agent with good oral activity in rats.
In vitro activity:
TBD
In vivo activity:
Rats were treated with LG 6-101 (16, 32, 64, 128, 256 mg kg-1 bodyweight), LG 6-102 (4, 8, 16, 32, 64 mg kg-1 bodyweight) and propafenone (32, 64, 128, 256 mg kg-1 bodyweight) by gavage twice daily during 4 days. Both, LG 6-101 and LG 6-102 showed strong antiarrhythmic effects against arrhythmias induced on the fifth day by infusion of aconitine (10 micrograms kg-1 min-1). Reference: Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. https://pubmed.ncbi.nlm.nih.gov/1620247/

Preparing Stock Solutions

The following data is based on the product molecular weight 426.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wascher TC, Dittrich P, Kukovetz WR. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. doi: 10.1007/BF00176627. PMID: 1620247. 2. Wascher TC, Dittrich P, Kukovetz WR. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. PMID: 2043172.
In vitro protocol:
TBD
In vivo protocol:
1. Wascher TC, Dittrich P, Kukovetz WR. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. doi: 10.1007/BF00176627. PMID: 1620247. 2. Wascher TC, Dittrich P, Kukovetz WR. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. PMID: 2043172.
1: Wascher TC, Dittrich P, Kukovetz WR. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. PubMed PMID: 1620247. 2: Wascher TC, Dittrich P, Kukovetz WR. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. PubMed PMID: 2043172.