Centazolone | CAS# 65793-50-2 | tranquillosedative drug

MedKoo Cat#: 412559 | Name: Centazolone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Centazolone is a tranquillosedative drug with action similar to that of chlordiazepoxide.

Chemical Structure

Centazolone

CAS#65793-50-2

Theoretical Analysis

MedKoo Cat#: 412559

Name: Centazolone

CAS#: 65793-50-2

Chemical Formula: C12H9N3O

Exact Mass: 211.0746

Molecular Weight: 211.22

Elemental Analysis: C, 68.24; H, 4.29; N, 19.89; O, 7.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Centazolone; NSC315852; NSC-315852; NSC 315852

IUPAC/Chemical Name

3-aminobenzo[g]quinazolin-4(3H)-one

InChi Key

CZXUQBVMAUWSBX-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H9N3O/c13-15-7-14-11-6-9-4-2-1-3-8(9)5-10(11)12(15)16/h1-7H,13H2

SMILES Code

NN1C=Nc(c2)c(C1=O)cc3c2cccc3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sethi N, Mukherjee K. Studies on 3-aminobenzo-6, 7 quinazolone-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part IX influence of centazolone on prenatal development in mice & rabbits. Indian J Exp Biol. 1978 Feb;16(2):206-7. PMID: 680813. 2: Puri VN, Kar K, George PA, Dhawan BN. Studies on 3-aminobenzo-6,7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compared: Part VIII--Evidence for the release of vasopressin in man & the rat following treatment with centazolone. Indian J Exp Biol. 1977 Dec;15(12):1137-8. PMID: 614203. 3: Prasad CR, Sharma JN, Dhawan BN. Studies on 3-aminobenzo-6, 7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part II--Assessment of tranquillosedative activity. Indian J Exp Biol. 1977 Dec;15(12):1115-9. PMID: 96017. 4: Dhawan BN, Sharma JN, Prasad CR, Srimal RC. Studies on 3-aminobenzo-6,7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part VII-Double blind crossover comparison with chlordiazepoxide in normal volunteers. Indian J Exp Biol. 1977 Dec;15(12):1134-6. PMID: 350764. 5: Laxmi CV, Dubey MP, Prasad CR, Dhawan BN. Some neurochemical effects of a new antianxiety agent centazolone. Indian J Exp Biol. 1984 Dec;22(12):649-52. PMID: 6534856. 6: Bhaduri AP, Khanna NM. Studies on 3-aminobenzo-6, 7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part I-- Synthesis & analytical studies. Indian J Exp Biol. 1977 Dec;15(12):1113-4. PMID: 614201. 7: Prasad CR, Sharma JN, Dhawan BN. Studies on 3-aminobenzo-6, 7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part IV--Acute toxicity & other pharmacological effects. Indian J Exp Biol. 1977 Dec;15(12):1125-7. PMID: 96018. 8: Roy AK, Srivastava GN, Sethi N, Mukherjee SK, Nityanand S. Studies on 3-aminobenzo-6, 7-quinazolone-4-one (centazolone, compound 65/469), a new tranquilosedative compound: Part V--Chronic toxicity studies. Indian J Exp Biol. 1977 Dec;15(12):1128-30. PMID: 96019. 9: Sharma JN, Prasad CR, Dhawan BN. Studies on 3-aminobenzo-6, 7-quinazoline-4-one (centazolone, compound 65/469), a new tranquillosedative compound: Part III--Assessment of central muscle relaxant activity. Indian J Exp Biol. 1977 Dec;15(12):1120-4. PMID: 614202. 10: Ananthanarayanan TV, Mohan Rao VK. Inhibition of rat brain monoamine oxidase by centazolone--a tranquillosedative. Indian J Med Res. 1978 Mar;67:485-9. PMID: 689725.