BMS-986299 | CAS#2242952-69-6 | NLRP3 agonist

MedKoo Cat#: 130459 | Name: BMS-986299

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-986299 is an agonist of the nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3). By activating NLRP3, BMS-986299 leads to NLRP3 inflammasome-mediated secretion of interleukin-8 (IL-8), which may promote anti-tumor activity of natural killer cells, potentially providing an alternate pathway in the treatment of certain cancers.

Chemical Structure

BMS-986299

CAS#2242952-69-6

Theoretical Analysis

MedKoo Cat#: 130459

Name: BMS-986299

CAS#: 2242952-69-6

Chemical Formula: C18H19N7O

Exact Mass: 349.1651

Molecular Weight: 349.40

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.88; H, 5.48; N, 28.06; O, 4.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BMS-986299; BMS986299; BMS 986299

IUPAC/Chemical Name

N-((4-amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl)methyl)-N-ethylacetamide

InChi Key

UHNRLQRZRNKOKU-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H19N7O/c1-3-25(10(2)26)9-15-22-16-12-5-4-11(13-6-7-20-24-13)8-14(12)21-18(19)17(16)23-15/h4-8H,3,9H2,1-2H3,(H2,19,21)(H,20,24)(H,22,23)

SMILES Code

CC(N(CC(N1)=NC2=C1C(N)=NC3=CC(C4=CC=NN4)=CC=C23)CC)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 349.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Bi C, Chadwick J, Davies ML, DelMonte AJ, Geng P, Glace AW, Green RA, Gurak JA Jr, Haley MW, He BL, Inankur B, Jamison CR, Joe CL, Kolotuchin S, Lin D, Lou S, Nye J, Ortiz A, Purdum GE, Rosso VW, Shah M, Simmons EM, Stevens JM, Strotman NA, Tan Y, Zhang L. Coupling-Condensation Strategy for the Convergent Synthesis of an Imidazole-Fused 2-Aminoquinoline NLRP3 Agonist. J Org Chem. 2023 Jan 6;88(1):384-394. doi: 10.1021/acs.joc.2c02395. Epub 2022 Dec 14. PMID: 36516991. 2. https://www.mdanderson.org/patients-family/diagnosis-treatment/clinical-trials/clinical-trials-index/clinical-trials-detail.ID2017-1041.html 3. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nlrp3-agonist-bms-986299