MedKoo Cat#: 598772 | Name: Medifoxamine fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Medifoxamine fumarate is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms.

Chemical Structure

Medifoxamine fumarate
Medifoxamine fumarate
CAS#16604-45-8

Theoretical Analysis

MedKoo Cat#: 598772

Name: Medifoxamine fumarate

CAS#: 16604-45-8

Chemical Formula: C20H22NO6

Exact Mass:

Molecular Weight: 372.39

Elemental Analysis: C, 64.51; H, 5.95; N, 3.76; O, 25.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Medifoxamine fumarate; LG 152; LG-152; LG152; Cledial; Geraxyl;
IUPAC/Chemical Name
mono(N,N-dimethyl-2,2-diphenoxyethan-1-aminium) monofumarate
InChi Key
CSQUJXBMSDQIKM-WLHGVMLRSA-M
InChi Code
InChI=1S/C16H19NO2.C4H4O4/c1-17(2)13-16(18-14-9-5-3-6-10-14)19-15-11-7-4-8-12-15;5-3(6)1-2-4(7)8/h3-12,16H,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/p-1/b;2-1+
SMILES Code
C[NH+](CC(OC1=CC=CC=C1)OC2=CC=CC=C2)C.O=C([O-])/C=C/C([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 372.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saleh S, Johnston A, Edeki T, Turner P. Tolerability and kinetics of intravenous medifoxamine in healthy volunteers. Int Clin Psychopharmacol. 1990 Apr;5(2):97-102. PubMed PMID: 2380545. 2: Martin P, Lemonnier F. [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine]. Encephale. 1994 Jul-Aug;20(4):427-35. French. PubMed PMID: 7988407. 3: Saleh S, Johnston A, Turner P. Absolute bioavailability and pharmacokinetics of medifoxamine in healthy humans. Br J Clin Pharmacol. 1990 Oct;30(4):621-4. PubMed PMID: 2291875; PubMed Central PMCID: PMC1368255. 4: Saleh S, Johnston A, Turner P. Medifoxamine: oral tolerance and pharmacokinetic study in healthy human volunteers. Eur J Clin Pharmacol. 1990;39(2):169-71. PubMed PMID: 2253668. 5: Randhawa MA, Blackett AN, Turner P. Spectrofluorimetric analysis and buccal absorption of medifoxamine. J Pharm Pharmacol. 1986 Aug;38(8):629-30. PubMed PMID: 2876086. 6: Olié JP, Galinowski A, Lehert P, Lemonnier F, Lôo H. [Randomized double-blind comparative study of the efficacy and tolerance of medifoxamine and imipramine in depressed patients]. Encephale. 1993 Jul-Aug;19(4):333-40. French. PubMed PMID: 8275921. 7: Saleh S, Turner P. Ocular hypotensive effects of medifoxamine. Br J Clin Pharmacol. 1992 Sep;34(3):269-71. PubMed PMID: 1389953; PubMed Central PMCID: PMC1381400. 8: Guy C, Rousset H, Cartry O, Lauwers A, Ollagnier M. [Fever caused by medifoxamine]. Presse Med. 1996 Jan 27;25(3):127. French. PubMed PMID: 8746090. 9: Marnata JB, Lamblin G, Gineston JL. [Fulminant hepatitis probably induced by medifoxamine (Cledial)]. Gastroenterol Clin Biol. 1991;15(8-9):659-60. French. PubMed PMID: 1752382. 10: Saleh S, Johnston A, Chanon M, Turner P. Determination of medifoxamine in plasma and urine by high-performance liquid chromatography. J Chromatogr. 1989 Nov 10;496(1):223-7. PubMed PMID: 2592513. 11: Lehert P, Poirier-Littre MF, Pringuey D, Galinowski A. New statistical proposals to evaluate the benefit/risk ratio of long-term treatment of depression: application to a one-year double-blind study comparing medifoxamine with fluoxetine. Clin Drug Investig. 1998;15(4):285-95. PubMed PMID: 18370483. 12: Gainsborough N, Nelson ML, Maskrey V, Swift CG, Jackson SH. The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers. Eur J Clin Pharmacol. 1994;46(2):163-6. PubMed PMID: 8039537. 13: Delaunay J, Meynard J, Elie JC. [Medifoxamine 50, an antidepressive drug without atropine-like side effects]. Ann Med Psychol (Paris). 1982 Jan;140(1):148-56. French. PubMed PMID: 7114665. 14: Saleh S, Johnston A, Turner P. Measurement of medifoxamine metabolites in urine by high-performance liquid chromatography. J Chromatogr. 1990 Jun 29;528(2):531-6. PubMed PMID: 2384591. 15: Galinowski A, Lehert P. Structural validity of MADRS during antidepressant treatment. Int Clin Psychopharmacol. 1995 Sep;10(3):157-61. PubMed PMID: 8675968. 16: Mitchell PB. Novel French antidepressants not available in the United States. Psychopharmacol Bull. 1995;31(3):509-19. PubMed PMID: 8668756. 17: Peutillot A. [Cledial]. Soins Psychiatr. 1987 Mar;(77):I-II. French. PubMed PMID: 3647615. 18: Dumortier G, Cabaret W, Stamatiadis L, Saba G, Benadhira R, Rocamora JF, Aubriot-Delmas B, Glikman J, Januel D. [Hepatic tolerance of atypical antipsychotic drugs]. Encephale. 2002 Nov-Dec;28(6 Pt 1):542-51. Review. French. PubMed PMID: 12506267.