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MedKoo Cat#: 461412 | Name: Ropitoin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ropitoin is is a novel antiarrhythmic drug.

Chemical Structure

Ropitoin
Ropitoin
CAS#56079-81-3 (free base)

Theoretical Analysis

MedKoo Cat#: 461412

Name: Ropitoin

CAS#: 56079-81-3 (free base)

Chemical Formula: C30H33N3O3

Exact Mass: 483.2522

Molecular Weight: 483.61

Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
56079-80-2 (HCl) 56079-81-3 (free base)
Synonym
Ropitoin; Ropitoinum; TR 2985; TR-2985; TR2985;
IUPAC/Chemical Name
5-(4-methoxyphenyl)-5-phenyl-3-(3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione
InChi Key
QAKVGHCHHKKDBQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H33N3O3/c1-36-27-15-13-26(14-16-27)30(25-11-6-3-7-12-25)28(34)33(29(35)31-30)20-8-19-32-21-17-24(18-22-32)23-9-4-2-5-10-23/h2-7,9-16,24H,8,17-22H2,1H3,(H,31,35)
SMILES Code
O=C1N(CCCN2CCC(C3=CC=CC=C3)CC2)C(C(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 483.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Elizalde A, Sanchéz-Chapula J. Effects of the novel antiarrhythmic compound TR 2985 (ropitoin) on action potentials of different mammalian cardiac tissues. Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):316-22. PubMed PMID: 3393234. 2: Valenzuela C, Sanchez-Chapula J. Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle. J Cardiovasc Pharmacol. 1989 Nov;14(5):783-9. PubMed PMID: 2481194. 3: Hong E, Gonzalez-Jasso E, Peon J. Antiarrhythmic activity of ropitoin in rats subjected to coronary artery ligation. Proc West Pharmacol Soc. 1986;29:15-7. PubMed PMID: 3763601.