MedKoo Cat#: 563491 | Name: 2002-H20

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2002-H20 is an inhibitior of Aβ42-induced cytotoxicity. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.

Chemical Structure

2002-H20
2002-H20
CAS#351520-91-7

Theoretical Analysis

MedKoo Cat#: 563491

Name: 2002-H20

CAS#: 351520-91-7

Chemical Formula: C20H15N3O3

Exact Mass: 345.1113

Molecular Weight: 345.35

Elemental Analysis: C, 69.56; H, 4.38; N, 12.17; O, 13.90

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Related CAS #
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Synonym
2002-H20; 2002 H20; 2002H20;
IUPAC/Chemical Name
4-amino-N-(3-(benzo[d]oxazol-2-yl)-4-hydroxyphenyl)benzamide
InChi Key
NVVIQGMTHCUMFT-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15N3O3/c21-13-7-5-12(6-8-13)19(25)22-14-9-10-17(24)15(11-14)20-23-16-3-1-2-4-18(16)26-20/h1-11,24H,21H2,(H,22,25)
SMILES Code
O=C(NC1=CC=C(O)C(C2=NC3=CC=CC=C3O2)=C1)C4=CC=C(N)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chebaro Y, Jiang P, Zang T, Mu Y, Nguyen PH, Mousseau N, Derreumaux P. Structures of Aβ17-42 trimers in isolation and with five small-molecule drugs using a hierarchical computational procedure. J Phys Chem B. 2012 Jul 26;116(29):8412-22. doi: 10.1021/jp2118778. Epub 2012 Feb 10. PubMed PMID: 22283547.