Synonym
RB 104; RB104; RB-104
IUPAC/Chemical Name
Benzenepropanoic acid, 4-hydroxy-alpha-(2-((3-(hydroxyamino)-3-oxo-1-(phenylmethyl)propyl)amino)-2-oxoethyl)-3-iodo-
InChi Key
SPYDLFCJSOZVCF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23IN2O6/c22-17-10-14(6-7-18(17)25)8-15(21(28)29)11-19(26)23-16(12-20(27)24-30)9-13-4-2-1-3-5-13/h1-7,10,15-16,25,30H,8-9,11-12H2,(H,23,26)(H,24,27)(H,28,29)
SMILES Code
O=C(O)C(CC(NC(CC1=CC=CC=C1)CC(NO)=O)=O)CC2=CC=C(O)C(I)=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
526.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hubner RA, Kubota E, Casley DJ, Johnston CI, Burrell LM. In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat. J Hypertens. 2001 May;19(5):941-6. PubMed PMID: 11393678.
2: Zappulla JP, Wickham L, Bawab W, Yang XF, Storozhuk MV, Castellucci VF, DesGroseillers L. Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica. J Neurosci. 1999 Jun 1;19(11):4280-92. PubMed PMID: 10341232.
3: Burrell LM, Farina N, Risvanis J, Woollard D, Casely D, Johnston CI. Inhibition of neutral endopeptidase, the degradative enzyme for natriuretic peptides, in rat kidney after oral SCH 42495. Clin Sci (Lond). 1997 Jul;93(1):43-50. PubMed PMID: 9279202.
4: Tharaux PL, Stefanski A, Ledoux S, Soleilhac JM, Ardaillou R, Dussaule JC. EGF and TGF-beta regulate neutral endopeptidase expression in renal vascular smooth muscle cells. Am J Physiol. 1997 Jun;272(6 Pt 1):C1836-43. PubMed PMID: 9227412.
5: Bawab W, Aloyz RS, Crine P, Roques BP, DesGroseillers L. Identification and characterization of a neutral endopeptidase activity in Aplysia californica. Biochem J. 1993 Dec 1;296 ( Pt 2):459-65. PubMed PMID: 8257438; PubMed Central PMCID: PMC1137717.
6: Landry C, Santagata P, Bawab W, Fournié-Zaluski MC, Roques BP, Vinay P, Crine P. Characterization of neutral endopeptidase 24.11 in dog glomeruli. Biochem J. 1993 May 1;291 ( Pt 3):773-9. PubMed PMID: 8489505; PubMed Central PMCID: PMC1132435.
7: Fournié-Zaluski MC, Soleilhac JM, Turcaud S, Laï-Kuen R, Crine P, Beaumont A, Roques BP. Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis". Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6388-92. PubMed PMID: 1385873; PubMed Central PMCID: PMC49506.
