VU0134992 is a selective blocker of the inward-rectifier potassium channel Kir4.1, exhibiting an IC₅₀ of 0.97 μM. It demonstrates approximately 10-fold selectivity over Kir4.1/5.1 concatemeric channels and over 30-fold selectivity compared to Kir1.1, Kir2.1, and Kir2.2 channels. In vivo studies have shown that oral administration of VU0134992 in rats leads to dose-dependent increases in urine output and excretion of sodium and potassium ions, highlighting its potential as a tool for exploring Kir4.1's role in renal function.
MedKoo Cat#: 564653
Name: VU0134992
CAS#: 755002-90-5
Chemical Formula: C20H31BrN2O2
Exact Mass: 410.1569
Molecular Weight: 411.38
Elemental Analysis: C, 58.39; H, 7.60; Br, 19.42; N, 6.81; O, 7.78
The following data is based on the product molecular weight 411.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
