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MedKoo Cat#: 461381 | Name: Etarotene

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etarotene is an ethylsulfonyl derivative of arotinoic acid with differentiation inducing and potential antineoplastic activities.

Chemical Structure

Etarotene
Etarotene
CAS#87719-32-2

Theoretical Analysis

MedKoo Cat#: 461381

Name: Etarotene

CAS#: 87719-32-2

Chemical Formula: C25H32O2S

Exact Mass: 396.2123

Molecular Weight: 396.58

Elemental Analysis: C, 75.71; H, 8.13; O, 8.07; S, 8.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Etarotene; Arotinoid ethyl sulphone; RO 15-1570; RO-15-1570; RO15-1570;
IUPAC/Chemical Name
(E)-6-(1-(4-(ethylsulfonyl)phenyl)prop-1-en-2-yl)-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene
InChi Key
UDAZCXVIYSIEFX-FBMGVBCBSA-N
InChi Code
InChI=1S/C25H32O2S/c1-7-28(26,27)21-11-8-19(9-12-21)16-18(2)20-10-13-22-23(17-20)25(5,6)15-14-24(22,3)4/h8-13,16-17H,7,14-15H2,1-6H3/b18-16+
SMILES Code
CC1(C)CCC(C)(C)C2=C1C=C(/C(C)=C/C3=CC=C(S(=O)(CC)=O)C=C3)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 396.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zheng ZS, Xue GZ, Prystowsky JH. Regulation of the induction of ornithine decarboxylase in keratinocytes by retinoids. Biochem J. 1995 Jul 1;309 ( Pt 1):159-65. PubMed PMID: 7619051; PubMed Central PMCID: PMC1135814. 2: Xue GZ, Zheng ZS, Chen RZ, Lloyd MB, Prystowsky JH. Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity. Biochem J. 1996 Oct 15;319 ( Pt 2):641-8. PubMed PMID: 8912706; PubMed Central PMCID: PMC1217815. 3: Wyss R, Bucheli F. Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching. III. Determination of the arotinoid sumarotene and its Z-isomer in human and animal plasma. J Chromatogr. 1992 Apr 15;576(1):111-20. PubMed PMID: 1500445.