Vintafolide (also known as EC145) is a folate-targeted conjugate of the chemotherapeutic agent vinblastine and a folate moiety, designed to selectively deliver cytotoxic payloads to cancer cells overexpressing folate receptor alpha (FRα), such as in ovarian, endometrial, and non-small cell lung cancers. In preclinical models, Vintafolide showed potent antitumor activity with nanomolar IC₅₀ values (typically 1–10 nM) in FRα-positive cell lines while sparing normal tissues.
MedKoo Cat#: 413557
Name: Vintafolide
CAS#: 742092-03-1
Chemical Formula: C86H109N21O26S2
Exact Mass: 1915.7294
Molecular Weight: 1917.06
Elemental Analysis: C, 53.88; H, 5.73; N, 15.34; O, 21.70; S, 3.34
The following data is based on the product molecular weight 1,917.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
