Synonym
Dehydroemetine; BT 436; BT-436; BT436; Mebadin; Ro 1-9334; Ro-1-9334; Ro1-9334;
IUPAC/Chemical Name
2-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-ethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline
InChi Key
XXLZPUYGHQWHRN-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,24-25,30H,6-12,17H2,1-5H3
SMILES Code
COC1=CC2=C(C=C1OC)CCNC2CC3=C(CC)CN4CCC5=CC(OC)=C(OC)C=C5C4C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
478.63
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: POWELL SJ, MACLEOD IN, WILMOT AJ, ELSDON-DEW R. THE TREATMENT OF ACUTE AMOEBIC DYSENTERY: TRIALS OF DEHYDROEMETINE, OF DEHYDROEMETINE-BISMUTH-IODIDE, AND OF DEHYDROEMETINE AND DEHYDROEMETINE-BISMUTH-IODIDE IN COMBINATION. Ann Trop Med Parasitol. 1965 Jun;59:205-7. PubMed PMID: 14345285.
2: Salako LA. The actions of dehydroemetine on isolated guinea-pig atria. Influence of ouabain and calcium. Br J Pharmacol. 1972 Dec;46(4):725-35. PubMed PMID: 4655270; PubMed Central PMCID: PMC1666376.
3: Jain NK, Madan A, Sharma TN, Sharma DK, Mandhana RG. Hepatopulmonary amoebiasis. Efficacy of various treatment regimens containing dehydroemetine and/or metronidazole. J Assoc Physicians India. 1990 Apr;38(4):269-71. PubMed PMID: 2202709.
4: Durotoye AO, Salako LA. The effect of dehydroemetine on isolated guinea-pig atria. Br J Pharmacol. 1972 Apr;44(4):723-31. PubMed PMID: 5041451; PubMed Central PMCID: PMC1665990.
5: Miller HH, Johnson RK, Donahue JD, Jondorf WR. Hepatic drug-metabolizing enzyme activity in rats pretreated with (-)-emetine or (plus or minus)-2,3-dehydroemetine. Biochem J. 1970 Apr;117(3):491-8. PubMed PMID: 4392930; PubMed Central PMCID: PMC1178951.
6: SARDESAI HV, SULE CR, GAVANKAR SS. Clinical trials with dehydroemetine (Ro 1-9334) in acute amebiasis. Indian J Med Sci. 1963 Apr;17:334-45. PubMed PMID: 13991475.
7: NANAVATI MB, DAMANY SJ, JOSHI HD. CLINICAL TRIAL OF DEHYDROEMETINE (RO 1-9334) IN AMOEDIASIS. Indian Pract. 1965 Mar;18:259-63. PubMed PMID: 14292163.
8: POWELL SJ, WILMOT AJ, MACLEOD IN, ELSDON-DEW R. DEHYDROEMETINE IN THE TREATMENT OF AMOEBIC LIVER ABSCESS. Ann Trop Med Parasitol. 1965 Jun;59:208-9. PubMed PMID: 14345286.
9: KAPADIA RM. CARDIOVASCULAR TOXICITY OF DEHYDROEMETINE IN AMOEBIASIS. J Indian Med Assoc. 1964 Nov 16;43:461-4. PubMed PMID: 14250826.
10: Hernandez-Perez E. Dehydroemetine therapy for herpes zoster. A comparison with corticosteroids. Cutis. 1980 Apr;25(4):424-6. PubMed PMID: 6102504.
11: Seshadri MS, John L, Varkey K, Koshy TS. Ventricular tachycardia in a patient on dehydroemetine and chloroquine for amoebic liver abscess. Med J Aust. 1979 May 5;1(9):406-7. PubMed PMID: 38383.
12: MUNZER D. EVALUATION OF THE EFFECTS OF DEHYDROEMETINE IN AMEBIASIS. Am J Gastroenterol. 1965 Jan;43:49-55. PubMed PMID: 14252602.
13: PATEL JC, DOSHI JC, DEHEJIA HV, BHARUCHA PE, DESHPANDE N. DEHYDROEMETINE IN THE TREATMENT OF AMOEBIASIS. A PRELIMINARY REPORT. J Indian Med Assoc. 1965 May 1;44:467-70. PubMed PMID: 14299042.
14: Farjo P. Dehydroemetine 'Roche' in amebic dysentery and amebic hepatitis in Iraq. Bull Endem Dis (Baghdad). 1964 Jun;6(1):70-4. PubMed PMID: 5825975.
15: Fouarge M, Dewulf M, Couvreur P, Roland M, Vranckx H. Development of dehydroemetine nanoparticles for the treatment of visceral leishmaniasis. J Microencapsul. 1989 Jan-Mar;6(1):29-34. PubMed PMID: 2565955.
16: Johnson RK, Wynn WT, Jondorf WR. Some aspects of the metabolism of 14C-labelled ( ) 2,3-dehydroemetine in the rat. Biochem J. 1971 Nov;125(2):26P-27P. PubMed PMID: 5144725; PubMed Central PMCID: PMC1178135.
17: Gulati OD, Makol R, Shah DS. Some characteristics of the adrenergic neurone blocking action of dehydroemetine. Br J Pharmacol. 1973 Jun;48(2):314-7. PubMed PMID: 4733732; PubMed Central PMCID: PMC1776205.
18: Rubidge CJ, Scragg JN, Powell SJ. Treatment of children with acute amoebic dysentery. Comparative trial of metronidazole against a combination of dehydroemetine, tetracycline, and diloxanide furoate. Arch Dis Child. 1970 Apr;45(240):196-7. PubMed PMID: 4315969; PubMed Central PMCID: PMC2020286.
19: PILLER M, STOHLER H. [Experimental bases of treatment of amebiasis with Dehydroemetine]. Praxis. 1963 Mar 7;52:273-5. German. PubMed PMID: 13943607.
20: Durotoye AO. The effect of dehydroemetine on vascular tissue. West Afr J Pharmacol Drug Res. 1976 Dec;3(2):119-27. PubMed PMID: 19879.
