Synonym
Mercaptomerin sodium; Letorin; Mercaptomerine sodique; Thiomerin sodium; Diucardyn sodium;
IUPAC/Chemical Name
sodium ((S)-3-((1R,3S)-3-carboxylato-2,2,3-trimethylcyclopentane-1-carboxamido)-2-methoxypropyl)((carboxylatomethyl)thio)mercury
InChi Key
RQXWFEXQGWCOGQ-UYJLKULWSA-K
InChi Code
InChI=1S/C14H24NO4.C2H4O2S.Hg.2Na/c1-9(19-5)8-15-11(16)10-6-7-14(4,12(17)18)13(10,2)3;3-2(4)1-5;;;/h9-10H,1,6-8H2,2-5H3,(H,15,16)(H,17,18);5H,1H2,(H,3,4);;;/q;;3*+1/p-3/t9-,10+,14-;;;;/m1..../s1
SMILES Code
O=C([O-])[C@@]1(C)CC[C@@H](C(NC[C@H](OC)C[Hg]SCC([O-])=O)=O)C1(C)C.[Na+].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
606.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: IGLAUER A. The treatment of cardiac edema with thiomerin sodium (mercaptomerin sodium). Cinci J Med. 1950 May;31(5):137-41. PubMed PMID: 15411732.
2: NEW and nonofficial remedies: mercaptomerin sodium; thiomerin sodium. J Am Med Assoc. 1950 Jul 8;143(10):895. PubMed PMID: 15421862.
3: CALESNICK B, WASE A, ALTARELLI VR. Distribution studies on radioactive Hg203 sodium mercaptomerin in animals. Proc Soc Exp Biol Med. 1960 Jan;103:22-5. PubMed PMID: 13806940.
4: THOMSEN AC. [The toxicity of mercaptomerin sodium and other mercurial diuretics]. Nord Med. 1956 Mar 29;55(13):436-7. Danish. PubMed PMID: 13334883.
5: POLLOCK BE, GILLESPIE JO. Self-administration of mercaptomerin sodium. U S Armed Forces Med J. 1951 Dec;2(12):1837-43. PubMed PMID: 14884338.
6: KREHBIEL S, STEWART HJ. Self-administration of a mercurial diuretic; experience of patients with mercaptomerin (thiomerin) sodium. J Am Med Assoc. 1951 May 19;146(3):250-3. PubMed PMID: 14823921.
7: CALESNICK B, WASE A. Absorption and excretion of radioactive Hg 203 mercaptomerin sodium in humans. J Nucl Med. 1963 Jan;4:29-34. PubMed PMID: 14017869.
8: AIKAWA JK, PILLIOD JP. Changes in renal tissue composition induced in rabbits by various intravenous doses of mercaptomerin sodium. Proc Soc Exp Biol Med. 1959 May;101(1):61-3. PubMed PMID: 13658191.
9: CAMPBELL DE. Modification by bromcresol green or probenecid of urinary excretion of sodium, chloride and potassium due to mercaptomerin. Acta Pharmacol Toxicol (Copenh). 1960;17:137-50. PubMed PMID: 13690219.
10: LEVY G, CALESNICK B, WASE A. RELATIONSHIP BETWEEN HG-203 EXCRETION RATE AND DIURETIC RESPONSE FOLLOWING HG-203 MERCAPTOMERIN SODIUM ADMINISTRATION. J Nucl Med. 1964 Apr;5:302-3. PubMed PMID: 14168703.
11: SAITO H. [EFFECTS OF OUABAIN, MERCAPTOMERIN AND HYDROCHLOROTHIAZIDE ON ATPASE ACTIVITY OF HUMAN ERYTHROCYTE MEMBRANE]. Nihon Yakurigaku Zasshi. 1964 Jul;60:372-6. Japanese. PubMed PMID: 14222759.
12: Avram MM, Iancu M, Gan AC. Medical nephrectomy: the use of metallic salts for treatment of end stage massive proteinuria and renal hypertension. Life Support Syst. 1983;1 Suppl 1:403-6. PubMed PMID: 6336453.
13: MAIZELS M, REMINGTON M. Mercaptomerin and water exchange in cortex slices of rat kidney. J Physiol. 1958 Sep 23;143(2):275-82. PubMed PMID: 13588554; PubMed Central PMCID: PMC1356804.
14: AIKAWA JK, PILLIOD JP. The rectal absorption of mercaptomerin tagged with Hg203. Am J Med Sci. 1958 Feb;235(2):179-82. PubMed PMID: 13498012.
15: NORTH JD, HOWIE RN, SIMS FH. Spironolactone used with mercaptomerin in the treatment of congestive cardiac failure. Med J Aust. 1961 Jul 15;48(2):92-5. PubMed PMID: 13729618.
16: Letteri JM, Wesson LG Jr. Calcium and magnesium excretion during glucose and mercaptomerin diuresis in man. Metabolism. 1969 Dec;18(12):1048-54. PubMed PMID: 5362691.
17: WEISSMAN L, GELFAND HH. Mercaptomerin sensitivity; report of a case. J Am Med Assoc. 1951 Dec 15;147(16):1559-61. PubMed PMID: 14873726.
18: CAMPBELL DE. The excretion of mercaptomerin and its diuretic effect modified by bromcresol green and probenecid. Acta Pharmacol Toxicol (Copenh). 1959;16:151-70. PubMed PMID: 13807239.
19: Olesen KH. A comparison of the diuretic action of mercaptomerin, ethacrynic acid and furosemide in congestive heart failure. Acta Med Scand. 1970 May;187(5):391-9. PubMed PMID: 5526957.
20: SMALLWOOD WC, MATTHEWS HL. Systemic reactions to a mercurial diuretic (mercaptomerin). Lancet. 1956 Jan 21;270(6908):121-3. PubMed PMID: 13287079.
