MedKoo Cat#: 145412 | Name: PNU-177553

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNU-177553 is an oxazolidinone. PNU-177553 binds only to the 50S subunit, with similar affinity as to the 70S ribosome, and has no affinity for the 30S subunit of oxazolidinones.

Chemical Structure

PNU-177553
PNU-177553
CAS#216868-86-9

Theoretical Analysis

MedKoo Cat#: 145412

Name: PNU-177553

CAS#: 216868-86-9

Chemical Formula: C16H20FN3O3S2

Exact Mass: 385.0930

Molecular Weight: 385.47

Elemental Analysis: C, 49.85; H, 5.23; F, 4.93; N, 10.90; O, 12.45; S, 16.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PNU-177553; PNU177553; PNU 177553;
IUPAC/Chemical Name
(S)-N-((3-(3-fluoro-4-(1-oxidothiomorpholino)phenyl)-2-oxooxazolidin-5-yl)methyl)ethanethioamide
InChi Key
XOLXODOYQGMVSK-ZDUSSCGKSA-N
InChi Code
1S/C16H20FN3O3S2/c1-11(24)18-9-13-10-20(16(21)23-13)12-2-3-15(14(17)8-12)19-4-6-25(22)7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,24)/t13-/m0/s1
SMILES Code
CC(=S)NC[C@H]1CN(C(=O)O1)C2=CC=C(N3CCS(=O)CC3)C(F)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou CC, Swaney SM, Shinabarger DL, Stockman BJ. 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes. Antimicrob Agents Chemother. 2002 Mar;46(3):625-9. doi: 10.1128/AAC.46.3.625-629.2002. PMID: 11850240; PMCID: PMC127483. 2: Bandyopadhyay R, Selbo J, Amidon GE, Hawley M. Application of powder X-ray diffraction in studying the compaction behavior of bulk pharmaceutical powders. J Pharm Sci. 2005 Nov;94(11):2520-30. doi: 10.1002/jps.20415. PMID: 16200547.