Lds 751 | CAS#76433-29-9 | nucleic acid stain

MedKoo Cat#: 559025 | Name: Lds 751

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lds 751 is a nucleic acid stain; preferentially stains nucleated cells.

Chemical Structure

Lds 751

CAS#76433-29-9

Theoretical Analysis

MedKoo Cat#: 559025

Name: Lds 751

CAS#: 76433-29-9

Chemical Formula: C21H23ClN2O4S

Exact Mass: 434.1067

Molecular Weight: 434.93

Elemental Analysis: C, 57.99; H, 5.33; Cl, 8.15; N, 6.44; O, 14.71; S, 7.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Lds 751; Lds-751; Lds751; Exciton;

IUPAC/Chemical Name

2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-3-ethylbenzo[d]thiazol-3-ium perchlorate

InChi Key

FWTLKTVVDHEQMM-UHFFFAOYSA-M

InChi Code

InChI=1S/C21H23N2S.ClHO4/c1-4-23-19-10-6-7-11-20(19)24-21(23)12-8-5-9-17-13-15-18(16-14-17)22(2)3;2-1(3,4)5/h5-16H,4H2,1-3H3;(H,2,3,4,5)/q+1;/p-1

SMILES Code

CN(C)c1ccc(/C=C/C=C/c2[n+](CC)c(cccc3)c3s2)cc1.O=Cl(=O)([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Snyder DS, Small PL. Staining of cellular mitochondria with LDS-751. J Immunol Methods. 2001 Nov 1;257(1-2):35-40. PubMed PMID: 11687236. 2: Lugo MR, Sharom FJ. Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. Biochemistry. 2005 Oct 25;44(42):14020-9. PubMed PMID: 16229491. 3: Lugo MR, Sharom FJ. Interaction of LDS-751 with the drug-binding site of P-glycoprotein: a Trp fluorescence steady-state and lifetime study. Arch Biochem Biophys. 2009 Dec;492(1-2):17-28. doi: 10.1016/j.abb.2009.10.002. Epub 2009 Oct 8. PubMed PMID: 19818729. 4: Shapiro AB, Ling V. Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein. Eur J Biochem. 1998 May 15;254(1):181-8. PubMed PMID: 9652412. 5: Lugo MR, Sharom FJ. Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site. Biochemistry. 2005 Jan 18;44(2):643-55. PubMed PMID: 15641790. 6: Maes ML, Davidson LB, McDonagh PF, Ritter LS. Comparison of sample fixation and the use of LDS-751 or anti-CD45 for leukocyte identification in mouse whole blood for flow cytometry. J Immunol Methods. 2007 Jan 30;319(1-2):79-86. Epub 2006 Dec 8. PubMed PMID: 17187818; PubMed Central PMCID: PMC1896319. 7: Terstappen LW, Shah VO, Conrad MP, Recktenwald D, Loken MR. Discriminating between damaged and intact cells in fixed flow cytometric samples. Cytometry. 1988 Sep;9(5):477-84. PubMed PMID: 2460298. 8: Clay AT, Sharom FJ. Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. Biochemistry. 2013 Jan 15;52(2):343-54. doi: 10.1021/bi301532c. Epub 2013 Jan 4. PubMed PMID: 23268645. 9: Neukirch AJ, Neumark DM, Kling MF, Prezhdo OV. Resolving multi-exciton generation by attosecond spectroscopy. Opt Express. 2014 Oct 20;22(21):26285-93. doi: 10.1364/OE.22.026285. PubMed PMID: 25401661. 10: Xue P, Yao B, Wang P, Gong P, Zhang Z, Lu R. Strong Fluorescent Smart Organogel as a Dual Sensing Material for Volatile Acid and Organic Amine Vapors. Chemistry. 2015 Nov 23;21(48):17508-15. doi: 10.1002/chem.201502401. Epub 2015 Oct 9. PubMed PMID: 26449736. 11: Ran NA, Kuik M, Love JA, Proctor CM, Nagao I, Bazan GC, Nguyen TQ. Understanding the charge-transfer state and singlet exciton emission from solution-processed small-molecule organic solar cells. Adv Mater. 2014 Nov 19;26(43):7405-12. doi: 10.1002/adma.201402423. Epub 2014 Sep 11. PubMed PMID: 25212949. 12: Fujita T, Huh J, Saikin SK, Brookes JC, Aspuru-Guzik A. Theoretical characterization of excitation energy transfer in chlorosome light-harvesting antennae from green sulfur bacteria. Photosynth Res. 2014 Jun;120(3):273-89. doi: 10.1007/s11120-014-9978-7. Epub 2014 Feb 7. PubMed PMID: 24504540. 13: Terstappen LW, Johnson D, Mickaels RA, Chen J, Olds G, Hawkins JT, Loken MR, Levin J. Multidimensional flow cytometric blood cell differentiation without erythrocyte lysis. Blood Cells. 1991;17(3):585-602; discussion 603-5. PubMed PMID: 1722123. 14: Pishchalnikov RY, Razjivin AP. From localized excited States to excitons: changing of conceptions of primary photosynthetic processes in the twentieth century. Biochemistry (Mosc). 2014 Mar;79(3):242-50. doi: 10.1134/S0006297914030109. PubMed PMID: 24821451. 15: McCarthy DA, Macey MG. A simple flow cytometric procedure for the determination of surface antigens on unfixed leucocytes in whole blood. J Immunol Methods. 1993 Aug 9;163(2):155-60. PubMed PMID: 7689085. 16: Wiczling P, Krzyzanski W. Flow cytometric assessment of homeostatic aging of reticulocytes in rats. Exp Hematol. 2008 Feb;36(2):119-27. doi: 10.1016/j.exphem.2007.09.002. PubMed PMID: 18206724. 17: Himmelfarb J, Hakim RM, Holbrook DG, Leeber DA, Ault KA. Detection of granulocyte reactive oxygen species formation in whole blood using flow cytometry. Cytometry. 1992;13(1):83-9. PubMed PMID: 1372205. 18: Klar TA, Jakobs S, Dyba M, Egner A, Hell SW. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8206-10. PubMed PMID: 10899992; PubMed Central PMCID: PMC26924. 19: Wang EJ, Barecki-Roach M, Johnson WW. Elevation of P-glycoprotein function by a catechin in green tea. Biochem Biophys Res Commun. 2002 Sep 20;297(2):412-8. PubMed PMID: 12237135. 20: Shen L, Chen Y, Li X, Li C. Tuning of the stability and energy levels of singlet exciton fission relevant excited states of pentacenes by site-specific substitution. J Mol Graph Model. 2016 May;66:187-95. doi: 10.1016/j.jmgm.2016.04.007. Epub 2016 Apr 22. PubMed PMID: 27131283.