Fluproquazone | CAS#40507-23-1 | analgesic

MedKoo Cat#: 461270 | Name: Fluproquazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluproquazone a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects. It was withdrawn during development due to liver toxicity.

Chemical Structure

Fluproquazone

CAS#40507-23-1

Theoretical Analysis

MedKoo Cat#: 461270

Name: Fluproquazone

CAS#: 40507-23-1

Chemical Formula: C18H17FN2O

Exact Mass: 296.1325

Molecular Weight: 296.34

Elemental Analysis: C, 72.95; H, 5.78; F, 6.41; N, 9.45; O, 5.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Fluproquazone; Tormosyl; 46-790; 46 790;

IUPAC/Chemical Name

4-(4-fluorophenyl)-1-isopropyl-7-methylquinazolin-2(1H)-one

InChi Key

ZWOUXWWGKJBAHQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3

SMILES Code

O=C1N(C(C)C)C2=C(C=CC(C)=C2)C(C3=CC=C(F)C=C3)=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 296.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Orwig BA, Dugger HA, Bhuta SI, Talbot KC, Schwarz HJ. The biotransformation of fluproquazone in man and several animal species. Arzneimittelforschung. 1981;31(5a):904-11. PubMed PMID: 6973984. 2: Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20. PubMed PMID: 6973986. 3: Jaegemann V, Kolb E, Pabst J, Lataste X. Fluproquazone in the management of strains and sprains. Arzneimittelforschung. 1981;31(5a):929-31. PubMed PMID: 6973989. 4: Wood AJ, von Graffenried B. Fluproquazone: analgesic activity in outpatients with non-migrainous headache. Arzneimittelforschung. 1981;31(5a):914-7. PubMed PMID: 7023493. 5: London R, Sundaram GS, Feldman S, Goldstein P. Episiotomy pain: efficacy and safety of fluproquazone compared to aspirin and placebo. Int J Gynaecol Obstet. 1983 Jun;21(3):251-5. PubMed PMID: 6139316. 6: Beveridge T, Crawford M. Effects of fluproquazone on platelet aggregation in man. Arzneimittelforschung. 1981;31(5a):937-40. PubMed PMID: 6973992. 7: Lataste X, Berchier P. Clinical evaluation of fluproquazone in post-operative pain. A report of double-blind comparative trials in patients after surgical interventions. Arzneimittelforschung. 1981;31(5a):920-4. PubMed PMID: 7023494. 8: Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vögtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5. PubMed PMID: 6973990. 9: Frerich D, Krumme U. Comparison of the analgesic efficacy of fluproquazone, propoxyphene and paracetamol in post-hysterectomy pain. Short communication. Arzneimittelforschung. 1981;31(5a):925-7. PubMed PMID: 6973987. 10: Gillberg R, Korsan-Bengtsen K, Magnusson B, Nyberg G. Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone. Scand J Rheumatol. 1981;10(4):342-6. PubMed PMID: 6976617. 11: Huskisson EC, Bryans R, Scott J. Fluproquazone for osteoarthritis. Rheumatol Rehabil. 1981 May;20(2):122-4. PubMed PMID: 7025173. 12: Ylikorkala O, Puolakka J, Kauppila A. Comparison between fluproquazone and indomethacin in treatment of primary dysmenorrhoea. Prostaglandins Med. 1981 Feb;6(2):217-21. PubMed PMID: 7017781. 13: Kunz J, Schneider W. [Therapy of dysmenorrhea with prostaglandin synthetase inhibitors: experiences with fluproquazone]. Schweiz Med Wochenschr. 1981 Sep 26;111(39):1451-5. German. PubMed PMID: 6794145. 14: Wheatley D. Analgesic properties of fluproquazone. Rheumatol Rehabil. 1982 May;21(2):98-100. PubMed PMID: 7043713. 15: Rüttimann G, Schön H, Madörin M, van Ryzin RJ, Richardson BP, Matter BE. Toxicological evaluation of fluproquazone. Arzneimittelforschung. 1981;31(5a):882-92. PubMed PMID: 6973981. 16: Williams JI, Bhuta SI, Jaffe JM, Migdalof BH, Schwarz HJ, Talbot KC, Brouillard JF, Donatsch P, Hodel C, Lemaire M, Meier J, Schweitzer A. Absorption, distribution, and excretion of fluproquazone in several animal species. Arzneimittelforschung. 1981;31(5a):897-904. PubMed PMID: 6973983. 17: Hill RC, Foote RW, Roemer D. The pharmacodynamic properties of fluproquazone. Arzneimittelforschung. 1981;31(5a):873-82. PubMed PMID: 6973980. 18: Herrmann U, Laube W, Roth F, Schultheiss HR, Berger M, Schürmann P, von Graffenried B, Nüesch E. Analgesic effect of fluproquazone in postoperative patients. Clin Pharmacol Ther. 1980 Mar;27(3):379-85. PubMed PMID: 6987026. 19: Gillberg RE, Korsan-Bengtsen K, Magnusson B, Nyberg G, Schütz W. Controlled comparison of gastric lesions and gastrointestinal blood loss with fluproquazone and acetylsalicylic acid (ASA) in healthy subjects. Arzneimittelforschung. 1981;31(5a):936-7. English, German. PubMed PMID: 6973991. 20: Hopfner R. Comparison of the analgesic efficacy of fluproquazone, pentazocine and placebo against postoperative pain in neurosurgical patients. short communication. Arzneimittelforschung. 1981;31(5a):927-9. PubMed PMID: 6973988.