MedKoo Cat#: 596463 | Name: Protheobromine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Protheobromine is a diuretic drug.

Chemical Structure

Protheobromine
Protheobromine
CAS#50-39-5

Theoretical Analysis

MedKoo Cat#: 596463

Name: Protheobromine

CAS#: 50-39-5

Chemical Formula: C10H14N4O2

Exact Mass: 222.1117

Molecular Weight: 222.24

Elemental Analysis: C, 54.04; H, 6.35; N, 25.21; O, 14.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Protheobromine; Pro-Cor; Protheobrominum; TEBE; Theocor; Vascopil; Bonicor;
IUPAC/Chemical Name
3,7-dimethyl-1-propyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
XJKSERUTELYNMR-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H14N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h6H,4-5H2,1-3H3
SMILES Code
O=C(N1CCC)N(C)C2=C(N(C)C=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 222.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lippert F. The effects of fluoride, strontium, theobromine and their combinations on caries lesion rehardening and fluoridation. Arch Oral Biol. 2017 Aug;80:217-221. doi: 10.1016/j.archoralbio.2017.04.022. Epub 2017 Apr 20. PubMed PMID: 28458181. 2: Al Shuwaili AH, Rasool BK, Abdulrasool AA. Optimization of elastic transfersomes formulations for transdermal delivery of pentoxifylline. Eur J Pharm Biopharm. 2016 May;102:101-14. doi: 10.1016/j.ejpb.2016.02.013. Epub 2016 Feb 27. PubMed PMID: 26925505. 3: Safarinejad MR, Asgari MA, Hosseini SY, Dadkhah F. A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie's disease. BJU Int. 2010 Jul;106(2):240-8. doi: 10.1111/j.1464-410X.2009.09041.x. Epub 2009 Oct 26. Retraction in: Safarinejad MR, Asgari MA, Hosseini SY, Dadkhah F. BJU Int. 2015 Mar;115(3):E10. PubMed PMID: 19863517. 4: Esquisatto LC, Costa SK, Camargo EA, Ribela MT, Brain SD, de Nucci G, Antunes E. The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells. Br J Pharmacol. 2001 Sep;134(1):108-15. PubMed PMID: 11522602; PubMed Central PMCID: PMC1572934. 5: Bharucha AE, Jorgensen R, Lichtman SN, LaRusso NF, Lindor KD. A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. Am J Gastroenterol. 2000 Sep;95(9):2338-42. PubMed PMID: 11007239. 6: Yuen KH, Wong JW, Peh KK, Julianto T, Choy WP. Comparative bioavailability study of two controlled-release pentoxifylline tablet preparations. Drug Dev Ind Pharm. 2000 Jul;26(7):803-7. PubMed PMID: 10872103.