Dacinostat HCl | CAS#591207-53-3 | Histone deacetylase inhibitor

MedKoo Cat#: 598397 | Name: Dacinostat HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dacinostat, also known as LAQ824, is a hydroxamate histone deacetylase inhibitor with potential anticancer activity. LAQ824 sensitized nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. LAQ824 reduced clonogenic survival of the H23 and H460 cell lines five-fold compared with controls and four-fold compared with either agent alone (P<0.001). In phase I trials, LAQ824 was well tolerated at doses that induced accumulation of histone acetylation, with higher doses inducing changes consistent with HSP90 inhibition.

Chemical Structure

Dacinostat HCl

CAS#Dacinostat HCl

Theoretical Analysis

MedKoo Cat#: 598397

Name: Dacinostat HCl

CAS#: Dacinostat HCl

Chemical Formula: C22H26ClN3O3

Exact Mass: 379.1896

Molecular Weight: 415.92

Elemental Analysis: C, 63.53; H, 6.30; Cl, 8.52; N, 10.10; O, 11.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

404951-53-7 (free base) 591207-53-3 (free base) Dacinostat HCl 927176-79-2 (TFA) 1347751-13-6 (lactate)

Synonym

Dacinostat HCl; NVP-LAQ824; NVP-LAQ 824; NVP-LAQ-824; LAQ-824; LAQ824; LAQ 824; Dacinostat.

IUPAC/Chemical Name

(E)-3-(4-(((2-(1H-indol-2-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide hydrochloride

InChi Key

CNOQMCROJPARKN-RRABGKBLSA-N

InChi Code

InChI=1S/C22H25N3O3.ClH/c26-14-13-25(12-11-20-15-19-3-1-2-4-21(19)23-20)16-18-7-5-17(6-8-18)9-10-22(27)24-28;/h1-10,15,23,26,28H,11-14,16H2,(H,24,27);1H/b10-9+;

SMILES Code

O=C(NO)/C=C/C1=CC=C(CN(CCC(N2)=CC3=C2C=CC=C3)CCO)C=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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