Holothurin B | CAS#11052-32-7 | toxin

MedKoo Cat#: 598311 | Name: Holothurin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Holothurin B is part of a group of toxins originally isolated from the sea cucumber Actinopyga agassizi. The holothurins belong to the class of compounds known as saponins.

Chemical Structure

Holothurin B

CAS#11052-32-7

Theoretical Analysis

MedKoo Cat#: 598311

Name: Holothurin B

CAS#: 11052-32-7

Chemical Formula: C41H64NaO18S

Exact Mass:

Molecular Weight: 899.99

Elemental Analysis: C, 54.72; H, 7.17; Na, 2.55; O, 32.00; S, 3.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Holothurin B;

IUPAC/Chemical Name

sodium (3R,4R,5R,6S)-6-(((3S,5R,8R,10S,12S,13S,17R)-17-((S)-1-((S)-5,5-dimethyltetrahydrofuran-2-yl)-1-hydroxyethyl)-12,17-dihydroxy-4,4,10,14-tetramethyl-19-oxo-1,2,3,4,5,6,7,8,10,12,14,15,16,17-tetradecahydro-14l5-14,13-(epoxymethano)cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl sulfate

InChi Key

KQXNWOMYLOTGKA-ZTCCDQCKSA-M

InChi Code

InChI=1S/C41H65O18S.Na/c1-19-27(43)29(45)30(46)32(54-19)56-31-28(44)22(59-60(50,51)52)18-53-33(31)55-25-12-14-37(6)20-17-24(42)40-34(47)58-41(40,8,21(20)9-10-23(37)36(25,4)5)16-15-39(40,49)38(7,48)26-11-13-35(2,3)57-26;/h17,19,21-33,42-46,48-49H,9-16,18H2,1-8H3,(H,50,51,52);/q;+1/p-1/t19-,21-,22-,23+,24+,25+,26+,27-,28+,29+,30-,31-,32+,33+,37-,38+,39+,40+;/m1./s1

SMILES Code

CC1(C)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)OS(=O)([O-])=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](C)O3)O)O)O)CC[C@]4(C)C5=C[C@H](O)[C@]6(C(O7)=O)[C@]([C@@](C)(O)[C@@H](O8)CCC8(C)C)(O)CCC67(C)[C@]5([H])CC[C@@]14[H].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 899.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yamasaki Y, Ito K, Enomoto Y, Sutko JL. Alterations by saponins of passive Ca2+ permeability and Na+-Ca2+ exchange activity of canine cardiac sarcolemmal vesicles. Biochim Biophys Acta. 1987 Mar 12;897(3):481-7. PubMed PMID: 3814597. 2: Enomoto Y, Ito K, Kawagoe Y, Morio Y, Yamasaki Y. Positive inotropic action of saponins on isolated atrial and papillary muscles from the guinea-pig. Br J Pharmacol. 1986 May;88(1):259-67. PubMed PMID: 3708218; PubMed Central PMCID: PMC1917120. 3: Popov AM, Anisimov MM, Ivanov AS, Korepanova EA, Antonov VF. [Characteristics of membrane activity of triterpene glycosides]. Antibiotiki. 1982 Apr;27(4):276-80. Russian. PubMed PMID: 7092199.